Rapid Screening of Substances identified from Phase Two of the Domestic Substances List Inventory Update

Results of the Screening Assessment

Environment and Climate Change Canada
Health Canada

August 2016

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Table of contents

Synopsis

As part of the Government of Canada 's Chemicals Management Plan, a section 71 notice for the second phase of the Domestic Substances List (DSL) Inventory Update (IU) initiative was published in the Canada Gazette, Part I on December 1, 2012 to collect data on approximately 2700 substances. As a result, 869 substances were identified as candidates for rapid screening. The substances included in this report were candidates for rapid screening because they were identified as being in commerce across Canada at a total of less than or equal to 1000 kg/year, according to information submitted pursuant to section 71 of Canadian Environmental Protection Act, 1999 (CEPA) regarding commercial activity in Canada under Phase Two of the DSL IU.

The majority of the 869 substances met the categorization criteria for persistence or bioaccumulation and inherent toxicity to human or non-human organisms or for greatest potential for exposure to humans under subsection 73(1) of CEPA. Some substances considered in this assessment had been identified as having health effects of concern based on classifications by other national or international agencies for carcinogenicity, genotoxicity, developmental toxicity or reproductive toxicity.

A rapid screening approach was applied that involved using conservative assumptions to identify substances that warrant further evaluation of their potential to cause harm to either human health or the environment, and those that are expected to have a low likelihood of causing harmful ecological or human health effects.

The ecological component consisted of two main steps to identify substances that warrant further evaluation of their potential to cause harm. The first step involved applying different exposure scenarios using assumptions that are protective of the environment. The second step involved a mechanical process to identify whether or not a substance appears on any of a wide range of lists or in sources of information relating to ecological hazard or exposure. This step recognized substances that have been identified by domestic or international initiatives as possibly being of greater concern due to their ecological hazard properties, or elevated potential for environmental release.

The human health component consisted of a process to determine whether the substance warrants further assessment based on the potential for exposure to the general population. Substances reported to be in commerce in Canada at less than or equal to 1000 kg/year are considered to warrant further assessment only if there is evidence of direct exposure (e.g., exposure from products or processed foods) for the general population in Canada. If the potential for exposure is considered to be negligible for a substance, then it is concluded that that substance is unlikely to cause harm to human health at current levels of exposure.

In total, 257 substances were identified as requiring further assessment (40 identified for both ecological and human health considerations, 199 identified for human health considerations only, and 18 identified for ecological considerations only). For the remaining 612 substances, this rapid screening approach indicated that current use patterns and quantities in commerce are unlikely to result in concerns for organisms or the broader integrity of the environment, or for human health in Canada. Although a risk to the environment or human health has not been identified for 612 substances, 39 of these substances in this assessment are recognized to have properties or effects of concern. There may be a concern for the environment or for human health if exposures to these substances were to increase.

Considering all available lines of evidence presented in this screening assessment, there is low risk of harm to organisms and the broader integrity of the environment from the 612 substances identified in Appendix C and D. It is concluded that the 612 substances do not meet the criteria under paragraphs 64(a) or 64(b) of CEPA as they are not entering the environment in a quantity or concentration or under conditions that have or may have an immediate or long-term harmful effect on the environment or its biological diversity or that constitute or may constitute a danger to the environment on which life depends.

From a human health perspective, direct or indirect exposure to the general population from environmental media (air, water, soil) to these 612 substances is expected to be negligible, and therefore the substances are unlikely to cause harm to human health at current levels of exposure. Based on the information presented in this screening assessment, it is concluded that the 612 substances listed in Appendix C and D do not meet the criteria under paragraph 64(c) of CEPA as they are not entering the environment in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health.

Conclusion

It is concluded that these 612 substances do not meet any of the criteria set out in section 64 of CEPA.

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Introduction

The Canadian Environmental Protection Act, 1999 (CEPA) (Canada 1999) requires the Minister of the Environment and the Minister of Health to conduct screening assessments of substances that have met the categorization criteria set out in subsection 73(1) of the Act to determine whether these substances present or may present a risk to the environment or human healthFootnote 1.

Under CEPA, screening assessments focus on information critical to determining whether a substance meets the criteria for defining a chemical as toxic as set out in section 64 of the Act, where:

"64. [...] a substance is toxic if it is entering or may enter the environment in a quantity or concentration or under conditions that

  1. have or may have an immediate or long-term harmful effect on the environment or its biological diversity;
  2. constitute or may constitute a danger to the environment on which life depends; or
  3. constitute or may constitute a danger in Canada to human life or health."

The Government of Canada has identified 869 substances as candidates for a rapid screening approach. Thirty-two substances from the Confidential Domestic Substances List (CDSL) were included as a part of the 869 substances in this rapid screening. A confidential Accession Number is given to a substance whose identity has been identified as confidential pursuant to paragraphs 3 to 7 of the Masked Name Regulations. Their identities have been masked according to sections 88 and 113 of CEPA in this report.

The 869 substances were identified as being in commerce at a total quantity across Canada of less than or equal to 1000 kg/year as reported through submission of information provided in response to a notice under section 71 of CEPA 1999 regarding commercial activity in Canada under Phase Two of the Domestic Substances List (DSL) Inventory Update (Canada 2014). The majority of these substances met the categorization criteria for persistence or bioaccumulation and inherent toxicity (PiT or BiT) to human or non-human organisms for Greatest Potential for Exposure (GPE), or under subsection 73(1) of CEPA. Substances may have additionally been identified as having health effects of concern based on classifications by other national or international agencies for carcinogenicity, genotoxicity, developmental toxicity or reproductive toxicity.

Substances that meet the above quantity criteria, but that have already been assessed and managed under CEPA, or are currently being addressed under other assessment activities, are not included in this assessment. Furthermore, assessments and conclusions pertaining to some of the substances in this rapid screening may be subsequently updated as part of future assessments if the substance is found to be part of a larger class or moiety. This assessment incorporates input from other programs within Environment Canada and Health Canada. Additionally, the draft of this Screening Assessment was subject to a 60-day public comment period. While external comments were taken into consideration, the final content and outcome of the screening assessment remain the responsibility of Health Canada and Environment Canada.

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Approach

Ecological component

The ecological component of the rapid screening approach, as illustrated in Figure 1, consists of multiple steps that address different factors relating to the potential for a substance to cause ecological harm. The approach is intended to be pragmatic, protective of the environment, and fairly rapid, largely making use of available or easily obtainable data and evaluation of the data.

Figure 1: Overview of the ecological rapid screening approach
Figure 1 (See long description below)
Long description for figure 1

Figure 1: Overview of the ecological rapid screening approach. The following figure illustrates the two steps for substances moving through the ecological approach. In the first step the estimated exposure values are compared with the aquatic effect level. If this ratio is equal to or above one it requires further assessment, if the ratio is less than one the substance moves on to step two. Finally, for substances where the ratio is equal to or above one and the substance was not considered to be in commerce in Canada, substances were considered for monitoring of changes in use profiles. Step 2 of the process begins with the mechanical filters process, during this stage substances may be directly flagged for further assessment or as not likely to cause ecological harm. A substance may also undergo a more detailed evaluation as part of the manual process if certain triggers are activated at the mechanical filters stage.

Step 1: Modelled exposure scenarios

The first step in the ecological component involves applying different scenarios or fate models to estimate environmental exposure. Two generic aquatic exposure scenarios were applied (described hereafter as scenarios A and B) to identify potential concerns near the point of discharge of a substance to the environment. These involve comparing conservative (i.e., ecologically protective) estimates of exposure in receiving waters with an effects threshold to evaluate whether a chemical is expected to cause harm to the local aquatic environment. A regional multi-media model named RAIDAR (Risk Assessment, IDentification And Ranking) is also applied. This fugacity-based model (described hereafter as scenario C) takes into account the combined characteristics of the substance in estimating potential harm in different environmental media (water, soil, and air), as well as in food chains. Figure 2 illustrates these exposure estimation approaches.

These approaches make use of available data from DSL categorization activities and Phase Two of the DSL Inventory Update. Data from the DSL Inventory Update includes use and quantity information from each reporting company. For those substances for which no data was received or the quantity reported was less than 100 kg, 100 kg was used for the quantity in the environmental exposure models. Data collected or estimated during categorization (Canada 2013) includes pivotal values for acute aquatic toxicity (iT), persistence and bioaccumulation, as well as physical/chemical properties.

While the generic aquatic exposure scenarios (A and B) have been developed to be conservative overall, the level of conservatism applied to individual parameters was selected to be moderate, since it is recognized that:

Rather, values in keeping with an overall worst case scenario have been used.

Figure 2: Overview of ecological exposure scenarios
Figure 2 (See long description below)
Long description for figure 2

Figure 2: Overview of ecological exposure scenarios. The following figure illustrations the three difference scenarios (A, B, and C) used in the ecological exposure scenarios. Scenario A is a manufacturing and blending scenario that has one point source release. Scenarios B and C are product use and disposal scenarios that include multiple point sources for release. Scenario C also includes non-point source releases. Different release scenarios are used; scenario A assumes a 5% release, scenario B assumes a 100% release, and scenario C uses a multimedia fugacity model to estimate the critical emission rate In scenario A, the exposure is localized, whereas in scenario B the exposure is as a result of releases from multiple waste water treatment systems. The estimated exposures from scenario A and B are compared to the aquatic effect threshold; if this ratio is equal to or above one the substance requires further assessment (beyond rapid screening), if the ratio is below one the substance proceeds to the second step of the ecological approach. In scenario C the critical emission rate (calculated through RAIDAR) is compared to the quality in commerce, if the risk assessment factor is below the cut-off value (0.001) the substance goes to step two of the ecological approach, if the risk assessment factor is above this value, the substance requires further assessment.

Scenario A: Industrial point source aquatic release

Scenario A is based on release from an industrial facility that is manufacturing the substance and/or using it in the blending or preparation of products. This scenario assumes the release of 5% of the substance from manufacturing and blending activities, based on conservative estimates for loss from cleaning of container residues (3%), transfer lines (1%) and process equipment (1%) (US EPA 1992). A conservative estimate of exposure (predicted environmental concentration (PEC)) resulting from the release of the substance to the aquatic environment from such an industrial point source is calculated as shown in the following equation.  Parameters used in Exposure Scenario A are described in Table 1.

PEC (mg/L) = (Qty (kg) x Release (%) x (1 – Wastewater Removal (%)))/(Duration (days) x (River flow (m3/s) + Wastewater flow (m3/s))) x (1000 (L/m3)/86400 (s/day))

The aquatic predicted no-effect concentration (PNEC) is derived as shown

Aquatic PNEC (mg/L) = CTV (mg/L)/AF

The PEC is compared to the PNEC to determine a risk quotient (PEC / PNEC). If the risk quotient is greater than one, this indicates that the conservatively estimated concentration in water exceeds the aquatic estimated no-effect level and that there exists a potential to cause harm in the aquatic ecosystem. A quotient below one indicates that concentrations that may cause an effect to sensitive aquatic organisms are not reached and therefore harm to aquatic organisms is unlikely under this scenario.

Table 1 - Parameters used in Exposure Scenario A
Abbrev.ParameterValueUnitsNotes
QtyMaximum quantity of substance used at one facilityQuantity from Inventory UpdatekgSubstance-specific
ReleaseRelease of substance during manufacturing or handling5%Based on conservative estimates of release from cleaning of container residues (3%), transfer lines (1%) and reactors (1%)
Wastewater
Removal
Wastewater Treatment System (WWTS) removal efficiency70%Conservative value for secondary treatment, recognizing biodegradation and sludge adsorption
DurationDuration over which substance is released150daysAssumes seasonal use of substance
Wastewater
flow
WWTS flow rate0.04m3/s10th percentile of municipal WWTS flow rates in Canada
River
flow
Flow of receiving watercourse1.84m3/s15th percentile of the distribution of receiving watercourse flows in the country (based on the distribution of the 50th percentile of flow rates); weighted by number of industries releasing to the receiving watercourse
-Factor combining conversion from kg to mg and m3 to L1000  
-Conversion factor from days to seconds86400  
CTVCritical Toxicity Value mg/LSubstance-specific; acute aquatic toxicity (iT pivotal value from categorization)
AFApplication factor100 To account for acute-to-chronic; lab to field; inter-species variability
Scenario B: Down-the-drain aquatic release from consumer products

The second scenario (residential releases to wastewater) considers the down-the-drain release of 100% of the substance that is contained in a consumer product, from multiple point-sources (i.e., wastewater system). While not all substances inherently have the characteristics that lend themselves to down-the-drain applications, this scenario is used to represent a worst-case. Under this scenario, a value for the PEC from down-the-drain release of a substance contained in products is calculated, as well as a value for the aquatic PNEC, as defined in the equations below. Parameters used in exposure scenario B are described in Table 2 below.

PEC (mg/L) = (Qty (kg) x Release (%) x (1 – Wastewater Removal (%)) x Population (persons))/(Duration (days) x RPE (persons)(River Flow (m3/s) + Wastewater Flow (m3/s) ))) x (1000 (L/m3)/86400 (s/day))

PNEC(mg/L) = CTV (mg/L)/AF

As was the case for Scenario A, the PEC and the PNEC are combined to determine a risk quotient (PEC / PNEC).

Note that river flow distributions used in the two scenarios are different. Likelihood of harm from industrial releases (scenario A) is dependent on the number of industrial facilities releasing to a water body. In that scenario, a distribution of the dilution capacities of receiving waters (river flow) was generated with a weighting by the number of industrial facilities releasing to the water body. Likelihood of harm from down-the-drain release of consumer products (scenario B) is dependent on the human population that may be releasing a substance to a wastewater treatment system. In this scenario, a distribution of the ratio of population of the community to the dilution capacity of the receiving water body was generated. As a result, the parameters "population", "wastewater flow rate" and "river flow" are inter-connected. In this scenario, it is this ratio that is important, not the actual values of the population or flow rates.

Table 2 - Parameters used in Exposure Scenario B
AbbreviationParameterValueUnitsNotes
QtyTotal quantity of substance used in CanadaQuantity from Inventory UpdatekgSubstance-specific
ReleaseRelease of substance from product during use100%Complete release for down-the-drain products assumed
Wastewater RemovalWWTS removal efficiency70%Conservative value for secondary treatment, recognizing biodegradation and sludge adsorption
PopulationPopulation of representative community100,000personsThe combined ratio of these three parameters corresponds to the 10th percentile of the distribution of dilution capacity of water body receiving WWTS effluent (river flow + WWTS flow) weighted by population served.
Wastewater flowWWTS flow rate0.66m3/sThe combined ratio of these three parameters corresponds to the 10th percentile of the distribution of dilution capacity of water body receiving WWTS effluent (river flow + WWTS flow) weighted by population served.
River FlowFlow of receiving watercourse3.58m3/sThe combined ratio of these three parameters corresponds to the 10th percentile of the distribution of dilution capacity of water body receiving WWTS effluent (river flow + WWTS flow) weighted by population served.
DurationDuration over which substance is released150daysAssuming seasonal use of substance
RPERegional product effect2,000,000personsValue set to represent population of a Canadian region in which total quantity of product could be used
-Factor combining conversion from kg to mg and m3 to L1000  
-Conversion factor from days to seconds86400  
CTVCritical Toxicity Value---mg/LSubstance-specific; acute aquatic toxicity (iT pivotal value from categorization)
AFApplication factor100 To account for acute-to-chronic; lab to field; inter-species variability
Scenario C: Life cycle release

Scenario C uses a fugacity-based multimedia modelling approach to address possible release of the substance over its full life-cycle. Such models assume substances released to the environment are distributed throughout a unit world – and are thus suitable for a disperse release scenario from all stages of the substance life-cycle (Mackay 2001).

This modelling approach also provides a "safety net" scenario, since it accounts for combined effects of a substance 's physical/chemical and hazard properties as well as considerations of exposure to different environmental media (water, air, soil, sediment) and organisms.

RAIDAR is a peer-reviewed fugacity-based model developed by the Canadian Environmental Modeling Network (CEMN) to assess chemicals for risk by estimating environmental fate and transport, bioaccumulation and exposure to organisms, and determining a critical emission rate (Arnot et al. 2006; Arnot and Mackay, 2008). An updated RAIDAR Ver.2.0 was used to run the simulations. The model has been revised to better address the fate and bioaccumulation for ionogenic organic chemicals (Armitage et al. 2013, Arnott 2011a,b)

A Level III fugacity model scenario was used to model the partitioning of substances into the environment. In this model, the substance is assumed to be continuously discharged at a constant rate and achieves a steady state condition in which input and output rates are equal. The loss processes are degradation reactions and advection. Unlike the simpler Level II fugacity model, equilibrium between media is not assumed and, in general, each medium is at a different fugacity. The Level III fugacity model scenario was run assuming a 33% release of the substance to each of air, water and soil for interpretation of RAIDAR results in this rapid screening approach. For ionogenic organic chemicals the scenario was run assuming a 100% release of the substance to water, since the substance is expected to partition to water.

Representative food webs are included in RAIDAR to assess routes of exposure of organisms to chemicals in the environment. The food web model takes the output from the fate and transport calculations for the substance (the concentration in the different environmental media) and estimates internal concentrations in some 20 biotic groups including plankton, vegetation, domestic animals, fish and wildlife, using data on the nature and quantity of diets, respiration, and growth rates. Essentially, each organism absorbs the chemical by respiring air (or by exchange at the gill-water interface in the case of fish) or by consuming water and other organisms (plants or animals). The concentration of the substance in each organism is generally calculated using these rates, absorption efficiencies, and the concentration in the respective media. The steady-state concentration in the organism is calculated from an input-output mass balance. The result is an estimate of fugacity and concentrations in the biota.

Using a multi-level, multi-media foodchain, the most sensitive endpoint is identified (based on toxicity and exposure potential) and a "critical emission rate" is calculated based on that sensitive endpoint. The estimated critical emission rate is then compared with an estimated potential emission rate (based on quantities in commerce) to determine a "risk assessment factor" or RAF.

Substances are ranked according to their critical emission rates and their RAF values. Substances identified as having greater potential for harm are considered as requiring further assessment. The model output also indicates substances that are unlikely to be of concern from releases to the environment through their life-cycle.

As outlined in a report on the application of RAIDAR in rapid screening (Arnot and Mackay 2007), there are some classes of substances (e.g., inorganic substances) for which application of the model was not designed or may not be appropriate. Substances belonging to such classes were identified and the model was not applied to them. A more detailed description of RAIDAR is contained in Environment Canada (2007a).

For the purpose of the rapid screening approach, the critical emission rate, the RAF and the media of concern are the most important outputs of RAIDAR. The use of the critical emission rate and the RAF allows identification of chemicals that are unlikely to be of concern because of their limited potential for exposure. Additionally, the identification of the most sensitive ecological endpoint allows consideration of environmental media and/or types of organisms that may not have been previously addressed in the rapid screening exposure scenarios A and B.

Possible outcomes from Step 1

There are three possible outcomes from Step 1:

Decisions regarding the need for future monitoring of changes in the use profiles are made when a new activity in relation to a substance could result in the substance being released in amounts or under conditions that may result in the substance posing an environmental risk. In the ecological portion of this screening assessment, decisions to recommend monitoring of changes in use profiles may be triggered for substances which are not currently in commerce (based on information collected under the DSL Inventory Update), but which could have a risk quotient value above one, if as little as 100 kg of the substance was brought into commerce. Based on back-calculation using the conservative ecological rapid screening exposure scenarios A (Industrial Point Source Aquatic Release) or B (Down-the-Drain Aquatic Release from Consumer Products), such a situation could occur if a substance has an acute aquatic toxicity value (lethal concentration to 50% of study organism (LC50) or equivalent) less than or equal to 0.0061 mg/L.

Step 2: Mechanical filters and manual processes

The second step of the ecological rapid screening approach involves verifying various information sources to confirm the likelihood that a substance may be of ecological concern. This approach uses "filters" (i.e., various information sources) and involves identifying whether or not a substance appears on different lists or sources of information relating to hazard or exposure. This step identifies substances that may have an elevated potential for environmental release or that have been identified by domestic or international sources as possibly being of greater concern due to their hazard properties.

Depending on the nature of the information sources, substances identified by the filters may be further evaluated manually within rapid screening or be identified as requiring further assessment. This manual process involves case-by-case evaluation to decide, for example, whether the information in the source that identified the substance is relevant to the situation in Canada. It may also involve collection and review of information from other sources that are not as amenable to evaluation using a mechanical approach. The manual process involves evaluation of the weight and relevance of information obtained from the full range of sources identified.

Many sources of information were evaluated. In selecting which lists or information sources to apply in rapid screening, there was an effort to limit the amount of overlap between lists. For example, secondary sources of information were removed if the primary source of information was also included. A list of the sources of information that were retained for the purpose of rapid screening can be found in Appendix A. A number of information sources were judged to be relevant for rapid screening, but were not amenable to being searched mechanically. These sources were included among those verified at the manual stage.

Possible outcomes from Step 2

There are two possible outcomes from Step 2:

Human health component

The process used to determine whether substances warrant further assessment from a human health perspective within the rapid screening approach is illustrated in Figure 3.

Figure 3: Overview of rapid screening approach - human health considerations
Figure 3 EN
Long description for figure 3

Figure 3: Overview of rapid screening approach – human health considerations. This figure is an overview of the human health approach. If a substance shows potential for indirect human exposure it requires further assessment. If the substance does not show the potential for indirect human exposure the potential of direct human exposure is investigated. If there is potential of direct exposure the substance requires further assessment, if there is no potential for direct human exposure the substance is classified as unlikely to cause harm to human health.

A key element of the characterization of potential risk to human health is determination of potential for exposure to the general population. Substances reported to be in commerce in Canada at less than or equal to 1000 kg/year were considered to result in potential exposure to the general population if there was evidence of direct exposure (e.g., exposure from products or processed foods). Otherwise, exposure to the general population was considered to be negligible and it can be concluded that the substance is unlikely to cause harm to health at current levels of exposure.

Given the reported quantities in commerce in Canada (less than or equal to 1000 kg) of these substances, indirect exposure to the general population from environmental media (e.g. air, water, soil) is not expected to be significant. Release of a substance to specific environmental media (i.e., water, air, soil) depends on factors such as where the substance is released and its physical/chemical properties. Conservative modelling estimates using a fugacity based modelling tool for applicable substances (ChemCan 2003), indicate that assuming 100% release of a substance (i.e., the maximum possible release for these substances of 1000 kg) to either air, water or soil, potential exposures would be predicted to be less than 10-6 mg/kg bw/day (i.e., less than 1 ng/kg bw/day). This represents a negligible exposure potential from indirect sources for these substances.

Depending on the use of the substance, direct exposure to the general population may be possible. Considerations for determination of direct exposure potential are described below and outlined in Figure 4.

Figure 4: Considerations for the determination of direct human exposure potential to chemical substances through direct use
Figure 4 EN
Long description for figure 4

Figure 4: Considerations for the determination of direct human exposure potential to chemical substances through direct use. This figure quantifies the steps the Human Health approach took to quantify exposure. If a substance is not used in or present in a product used by Canadians it was quantified as having a low potential for exposure. If the substance is used in or present in a product used by Canadians the potential of the substance leaching or migrating out of the final product was investigated. If it was believed that the potential for leaching or migrating out of the final product was low the substance was quantified as having a low potential for exposure. If it was believed or is unknown that the substance may leach or migrate out of a final product the substance was quantified as having a potential for human exposure.

The term "direct use" refers to the use of a chemical substance that is directly, or as part of a mixture, a product, or a manufactured item, sold to or made available to Canadians for their use.

"Direct use" does not include exposures from chemical products used by workers in an industrial setting or other workplace.

A user is considered to be anyone from the general public who has access to a product that is advertised, imported or sold in CanadaFootnote 2.

To determine if a substance is used in or present in a product used by Canadians, numerous sources of both domestic and international use and product information were consulted, including but not limited to:

Domestic

International

Based on the information identified from these resources, the following considerations were used to determine potential for direct exposure:

  1. Substances to which direct exposures to the general population are not expected include, but are not limited to, substances:
    1. used only as intermediates in the manufacturing process;
    2. used only for industrial use; or
    3. used only for research purposes.
  2. Substances with potential for direct exposure to the general population include those that are present, either intentionally or unintentionally, in products or manufactured items that are commonly used by Canadians. These include, but are not limited to, substances used in:
    • products intended for use by children, and manufactured items such as plastic or wooden toys;
    • personal care productsFootnote 3;
    • commercial paints and inks;
    • commercial adhesives;
    • hobby activities or do-it-yourself products;
    • clothing, fabric and other textiles, including bedding and furniture
    • cleaning products;
    • food additives and packaging; or
    • fragrances or flavourantsFootnote 4.
  3. Information on potential for the substance to migrate from products was also considered, including the type of product that the substance is present in, the substance 's functional use in that product, as well as the substance 's physical-chemical properties. For example, direct exposure would not be expected to occur for a substance used as a curing agent in a polymer as the substance would be reacted into the stable matrices of the cured polymer and would therefore not typically be available for migration. If this information is not known for a substance, it was assumed that the substance may be migrating out of the final product, which may lead to direct exposure for users.

Through the evaluation, some uses were identified that could result in direct exposure; however, these uses are already being regulated under other Acts:

  1. Fertilizers- The direct use of fertilizers is regulated under the Fertilizers Act. As a consequence, if the only use (with a potential for direct exposure) identified for a substance was as a fertilizer (or component thereof), that use was considered to be regulated under the Fertilizers ActFootnote 5, and as a result, this use was no longer considered in the evaluation. These substances have been flagged in Appendix C;
  2. Pharmaceuticals – The direct use of pharmaceuticals is regulated under the Food and Drugs Act. This use was not considered further in the evaluation of potential for direct exposure to the general population in this screening assessment. Substances which were found to be used only in pharmaceutical (veterinary and/or human) applications, with information indicating volume levels less than 1000 kg per year in Canada, have been identified as requiring no further action in this rapid screening approach. These substances have been flagged in Appendix C;
  3. Pesticide formulants –In situations where the only use identified for a substance was as a formulant in a pesticide product registered under the Pest Control Products Act(PCPA), this potential for direct exposure to the general public was not considered further in this screening assessment. Substances in pest control products registered under the PCPA have undergone an ecological and human health risk assessment by the Pest Management Regulatory Agency (PMRA) according to the intended use and labelling as part of their registration process. The substances used as formulants were considered separately from those identified as active ingredients in registered pesticide products, as the formulants, while components of pesticide products, do not provide a function(s) that is/are unique to pesticides. However, in the case of the formulants flagged in Appendix C, no uses were identified in Canada for these substances, other than their listing as pesticide formulants (PMRA 2010); and
  4. Historical active pesticide ingredients- these are substances which were registered as active ingredients in pesticide products in Canada historically, but do not have any current registered uses in pesticides in Canada. These substances have been flagged in Appendix C.

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Screening Assessment Results

Assessment of potential to cause ecological harm

In this section, an overview of the results obtained at each step of rapid screening of the substances covered under this assessment is provided. These results are summarized in Figure 5.

Figure 5: Summary of screening assessment results - ecological considerations
Figure (See long description below)
Long description for figure 5

Figure 5: Summary of screening assessment results – ecological considerations. The following figure illustrates the two steps for 869 substances moving through the ecological approach and identifies how many substances are retained in each step. In the first step the estimated exposure values are compared with the aquatic effect level. If this ratio is equal to or above one the substance requires further assessment (52 substances fell into this category). If the ratio is less than one, the substance moves on to step two (786 substances fell into this category). Finally, for a substance where the ratio is equal to or above one, and the substance was not considered to be in commerce in Canada, the substance was considered for monitoring of changes in use profiles (31 substances fell into this category). Step 2 of the process begins with the mechanical filters process. During this stage substances may be directly flagged for further assessment (no substances) or as requiring a more detailed evaluation as part of the manual process (786 substances). The manual process identified 6 substances for further assessment and 780 substances that were unlikely to cause ecological harm. In total 811 substances were found unlikely to cause ecological harm (780 plus 31 substances considered for monitoring for changes in use profiles).

* Values in above figure represent ecological decisions only, when human health considerations are taken into account the number of substances that require monitoring for changes in use profiles and that are not expected to cause harm will decrease as some of the substances will require further assessment due to human health considerations.

Step 1: Modelled exposure scenarios

In this assessment, quantities that were used in the exposure scenarios were obtained through the Phase Two of the DSL Inventory Update (Canada 2012).

Generic aquatic scenarios

The industrial releases scenario (scenario A) identified 129 substances as being of potential concern, while the residential releases scenario (scenario B) identified 86 substances, all of which were also identified by the industrial release scenario. These 129 substances (or 15% of the 869 evaluated) were initially identified by these scenarios as requiring further assessment. However, results from the Second Phase of the DSL Inventory Update indicate that 77 of these 126 substances are no longer in commerce in Canada above the reporting threshold (i.e. 100 kg). As indicated in the ecological component portion of the Approach section of this report, activities with as low as 100 kg per year of a substance could pose a risk if that substance has an acute aquatic toxicity value (LC50 or equivalent) less than or equal to 0.0061 mg/L. 

Of the above-mentioned 77 substances, 46 substances are not expected to be a significant contributor to the presence of the substance in the environment. For example, there are a number of  substances where the pivotal inherent toxicity value identified during categorization of the DSL and applied in this rapid screening evaluation, was based on the ecotoxicity of the free metal ion expected to be liberated during dissolution/transformation of the substance under natural conditions. For example, an organic metal salt will dissolve and liberate a metal cation and an anionic organic moiety when present in water. However, in the case of these substances--all of which are believed to have very little or no commercial presence at this time--becoming a significant contributor to the presence of the total metal moiety in the environment in the future, relative to other sources of release, is unlikely. Therefore, only 31 of these substances are proposed flagged as having ecological effects of potential concern (see Appendix E).

RAIDAR

RAIDAR and similar models are not applicable to all categories of substances encountered on the DSL. RAIDAR was applied to substances described in Arnot and Mackay (2007): conventional organics; dissociating organic acids; and dissociating organic bases. Therefore, of the 869 substances evaluated in Step 1, 236 (or 27%) were modelled using RAIDAR. However, higher confidence was only achieved with the modelling of the organic substances. A spreadsheet includes all input values and results from application of RAIDAR to these substances (ARC 2014). As with other models, results from RAIDAR depend on the quality and quantity of the available substance-specific data.

In order to identify which substances are unlikely to have the potential to cause ecological harm, it is necessary to select a cut-off value for the RAF. A value of 0.001 was selected, which is equivalent to an uncertainty factor of 1000. Selection of this conservative value allows for up to a 1000-fold error in the model results owing to uncertainties in the quantity of the substance in commerce and other model inputs, such as physical-chemical properties. The ability of RAIDAR to discriminate potential for ecological harm based on the characteristics of substances is discussed further in Environment Canada (2007b).

Based on the described model scenario and the selected RAF cut-off value, 23 of the 236 substances that were evaluated using RAIDAR were identified as having potential for harmful effects if released at the reporting thresholds used in the DSL Inventory Update  (Figure 6) and thus requiring further assessment. RAIDAR identified three additional substances for further assessment beyond the substances identified in release scenarios A and B.

Figure 6: Risk Assessment Factor (RAF) results based on the RAIDAR model. (The dashed line represents the RAF cut-off of value of 0.001)
Figure 6 (See long description below)
Long description for figure 6

Figure 6: Risk Assessment Factor (RAF) results based on the RAIDAR model. This graph ranks the RAF for the 236 substances which were modeled using RAIDAR. In order to identify which substances are unlikely to have the potential to cause ecological harm, it is necessary to select a cut-off value for the RAF. A value of 0.001 was selected, which is equivalent to an uncertainty factor of 1000. A total of 23 substances were above this cut-off and were identified for further assessment.

Step 2: Mechanical filters and manual process

Appendix A shows the number of substances that were identified by each of the mechanical filters for the 869 substances that were evaluated in this rapid screening exercise. In contrast to the rapid screening approach outlined in Environment Canada 2007a, the appearance of a substance on one or more of the six international lists of High Production Volume (HPV) chemicals did not automatically result in the substance being identified for further assessment due to the availability of recent Canadian data (Canada 2014) on these substances. Substance-by-substance evaluation at the manual process stage was based on consideration of the available information to evaluate whether the substance has hazard properties or characteristics, or an elevated potential for environmental release, that may not have been adequately addressed using the exposure scenarios in Step 1.

As a result of manual screening, six substances were identified as requiring further screening assessment due to additional toxicity data.

Summary of results from ecological assessment

In total, 58 of the substances evaluated using the ecological rapid screening approach were identified as warranting further assessment from an ecological perspective. A list of these substances is provided in Appendix B. The other 811 substances were identified as posing a low risk of harm to organisms or the broader integrity of the environment at current levels of exposure. Thirty-one of these substances were identified as having potential ecological effects of concern as a result of their relatively high aquatic toxicity (Appendix E).

Assessment of potential to cause harm to human health

Of the 869 substances examined from a human health perspective, 239 substances were identified as having the potential to result in direct exposure to the general population and therefore warrant further assessment of the exposure and hazard potential of these substances. A list of the substances with potential for direct exposure to the general population, and therefore requiring further assessment, is provided in Appendix B.

Exposure to the general population was considered to be negligible for the remaining 630 substances

However, eight substances not identified for further assessment at this time may be recommended to be monitored for changes in use profiles (identified in Appendix C) based on high hazard concerns. These substances have been identified as havinghealth effects of concern based on classifications by other national or international agencies for carcinogenicity, genotoxicity, developmental toxicity or reproductive toxicity (see Appendix F).

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Summary of uncertainties

It is recognized that conclusions resulting from the use of a rapid screening approach have associated uncertainties. However, the use of a wide range of filters (relating to both exposure potential and hazard concerns identified for each substance), as well as the use of conservative exposure scenarios give confidence that substances identified as not requiring further assessment are unlikely to be of concern.

Values for physical/chemical and hazard properties derived during categorization of the DSL were used as input for the modelling work for the ecological assessment. As is recognized in documentation associated with categorization, there are uncertainties in these values, in particular with those that have been estimated using different modelling approaches. Extreme values that were estimated by models were replaced by limiting values of physical/chemical properties or alternatively-derived toxicity values, prior to using them as input for RAIDAR modelling as part of rapid screening (ARC 2014).

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Conclusion

In total, from both ecological and human health assessments, 257 of the 869 substances were identified as requiring further assessment (Appendix B).

Based on the information available, it is concluded that the remaining 612 substances are not entering the environment in a quantity or concentration or under conditions that have or may have an immediate or long-term harmful effect on the environment or its biological diversity, that constitute or may constitute a danger to the environment on which life depends, or that constitute or may constitute a danger in Canada to human life or health. It is therefore concluded that these 612 substances (Appendix C and D) do not meet any of the criteria set out in section 64 of CEPA 1999.

As these 612 substances are listed on the DSL, they are not subject to notification under the New Substance Notification Regulations (Chemicals and Polymers). Although a risk to the environment or human health has not been identified, 39 substances (31 ecological, 8 human health) in this assessment are recognized to have properties or effects of concern (see Appendix E and F). There may be a concern for the environment or for human health if exposures to these substances were to increase. 

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References

ARC. 2014. Parameterization and Application of the RAIDAR Model to Support Prioritization and Assessment of Substances. Report prepared by ARC Arnot Research & Consulting Inc., Toronto, ON, for the Existing Substances Division, Environment Canada, Gatineau, QC, Canada.

Armitage, J. M., J.A. Arnot, F. Wania, D. Mackay 2013. Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish. Environ. Toxicol. Chem. 32: 115-128, Arnot, J.A., D. Mackay, E. Webster and J. Southwood. 2006. Screening level risk assessment model for chemical fate and effects in the environment. Environ. Sci. Technol. 40:2316-2323

Arnot, J. and Mackay, D. 2007. Risk prioritization for a subset of Domestic Substances List chemicals using the RAIDAR model. Report prepared by the Canadian Environmental Modelling Centre, Trent University, ON, for the Existing Substances Division, Environment Canada, Gatineau, QC, Canada. CEMC Report No.: 200703.

Arnot, J. A., D. Mackay 2008. Policies for chemical hazard and risk priority setting: Can persistence, bioaccumulation, toxicity and quantity information be combined? Environ. Sci. Technol. 42: 4648-4654.

Arnot, J. A. 2011a. Updating the raidar and fhx models to aid in the prioritization and assessments of chemicals including ionisable substances. Draft technical report for Health Canada.; Health Canada: Ottawa, ON, March 25, 2011; p 39.

Arnot, J. A. 2011b. Exploring the fate, bioaccumulation and exposure potential of ionogenic chemicals released to the environment using the raidar model. Draft technical report prepared for unilever.; ARC Arnot Research & Consulting Inc.

Canada. 1999. Canadian Environmental Protection Act, 1999. S.C., 1999, c. 33.

Canada. 2012. Canadian Environmental Protection Act, 1999: Notice with respect to certain inanimate substances (chemicals) on the Domestic Substances List, Vol. 146, No. 48, 1 December, 2012.

Canada. 2013. Search engine for the results of DSL Categorization. [March 2014].

Canada. 2014. Draft results from Phase Two of the Domestic Substances List Inventory Update. Environment Canada, Gatineau, QC, Canada

ChemCAN [Level III fugacity model of regional fate of chemicals]. 2003. Version 6.00. Peterborough (ON): Trent University, Canadian Centre for Environmental Modelling and Chemistry.

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Environment Canada. 2007a. Technical Approach for "Rapid Screening" of Substances of Lower Ecological Concern. Existing Substances Division, Environment Canada, Gatineau, QC, Canada.

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Mackay, D. 2001. "Multimedia Environmental Models: The Fugacity Approach - Second Edition", Lewis Publishers, Boca Raton, pp.1-261.

[NHPID] Natural Health Products Ingredients Database [database on the internet]. 2014. Health Canada, Government of Canada; [Accessed January-February 2014].

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Appendicies

Appendix A: Number of substances for which data was available, by source

Number of substances for which data was available, by source
Mechanical FiltersNumber of Substances
OECD HPV86
EU HPV47
ICCA HPV17
US HPV11
US EXTENDED HPV0
Japan HPV8
Australia HPV2
REACH Dossier Published/disseminated54
Toxic Substances Control Act – 12(b) Export Notification (US)4
National Pollutant Release Inventory (CA)7
Toxics Release Inventory (US)19
National Pollutant Inventory (AU)0
Pollutant Release & Transfer Register (JN)7
(NClassification) R52 (EU)3
(NClassification) R53 (EU)0
(NClassification) R52,53 (EU)3
(NClassification) N; R50 (EU)48
(NClassification) N: R50,53 (EU)44
(NClassification) N: R51,53 (EU)18
Banned or Severely Restricted Pesticides (US )13
PBT List (US)0
Priority Substances List (EU )0
EU PBT List (EUROPE)2
List of Substances Banned/Severely restricted in EU (EUROPE)4
Great Lakes Binational Toxics List (CA/US)0
PIC List (UN)4
CEPA 1999 Section 200 Environmental Emergencies List (CA)4
PSL2 Nomination Dossiers (CA)3
ARET List (CA)3
Great Lakes 211 Air Toxics (CA/US)7
NAPS (CA)0
Pest Control Products Act Registered Active Ingredients (CA)13
Air Toxics / Hot Spots Chemicals (California)13
Clean Water Act Priority Pollutants (US)5
Superfund Site Chemicals (US)35
Hazardous Constituents Under RCRA (US)0
Nordic Council List of Chemicals Hazardous to Environment (EU)68
OSPAR List (EU)14
UNEP/FAO/WHO Inchem Pesticide Classification (UN)0
Toxic Chemicals List (China)9
Camford Product Information Profiles (CA)0
BUA Reports (DE)5
UNEP EHC (UN)12
RAIS Tox Profile (US)2
TSCATS (US)59
HSDB Record (US)132
NTP Reports / Studies (US)43
ChemFate – Syracuse Research Corporation (US)5
Datalog – Syracuse Research Corporation (US)26
CESARS – Ontario Database (CA/US)27

Appendix B: Substances identified as requiring further assessment

Substances identified as requiring further assessment
CAS RNaDomestic Substances List namePotential Ecological concernPotential Human Health concern
50-48-61-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-NoYes
57-09-01-Hexadecanaminium, N,N,N-trimethyl-, bromideNoYes
57-97-6Benz[a]anthracene, 7,12-dimethyl-YesNo
58-20-8Androst-4-en-3-one, 17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-NoYes
59-50-7Phenol, 4-chloro-3-methyl-YesYes
67-97-09,10-Secocholesta-5,7,10(19)-trien-3-ol, (3β,5Z,7E)-YesYes
68-26-8RetinolNoYes
77-09-81(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-NoYes
78-21-7Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfateNoYes
79-74-31,4-Benzenediol, 2,5-bis(1,1-dimethylpropyl)-YesNo
87-22-9Benzoic acid, 2-hydroxy-, 2-phenylethyl esterNoYes
88-84-6Azulene, 1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethylidene)-, (1S-cis)-NoYes
91-51-0Benzoic acid, 2-[[3-[4-(1,1-dimethylethyl)phenyl]-2-methylpropylidene]amino]-, methyl esterYesYes
93-58-3Benzoic acid, methyl esterNoYes
93-89-0Benzoic acid, ethyl esterNoYes
106-70-7Hexanoic acid, methyl esterNoYes
108-93-0CyclohexanolNoYes
109-29-5Oxacycloheptadecan-2-oneYesYes
109-87-5Methane, dimethoxy-NoYes
109-94-4Formic acid, ethyl esterNoYes
110-00-9FuranNoYes
111-96-6Ethane, 1,1 '-oxybis[2-methoxy-NoYes
112-38-910-Undecenoic acidNoYes
116-31-4RetinalNoYes
117-98-66-Azulenol, 1,2,3,3a,4,5,6,8a-octahydro-4,8-dimethyl-2-(1-methylethylidene)-, acetateNoYes
120-11-6Benzene, 2-methoxy-1-(phenylmethoxy)-4-(1-propenyl)-NoYes
120-24-1Benzeneacetic acid, 2-methoxy-4-(1-propenyl)phenyl esterNoYes
120-50-3Benzoic acid, 2-methylpropyl esterNoYes
122-68-92-Propenoic acid, 3-phenyl-, 3-phenylpropyl esterNoYes
122-79-2Acetic acid, phenyl esterNoYes
124-13-0OctanalNoYes
126-13-6α-D-Glucopyranoside, 6-O-acetyl-1,3,4-tris-O-( 2-methyl-1-oxopropyl)-ß-D-fructofuranosyl, 6-acetate 2,3,4-tris(2-methylpropanoate)NoYes
133-14-2Peroxide, bis(2,4-dichlorobenzoyl)YesNo
134-09-8Cyclohexanol, 5-methyl-2-(1-methylethyl)-, 2-aminobenzoateNoYes
137-29-1Copper, bis(dimethylcarbamodithioato-S,S ')-, (SP-4-1)-YesNo
141-79-73-Penten-2-one, 4-methyl-NoYes
142-71-2Acetic acid, copper(2++) saltNoYes
150-60-7Disulfide, bis(phenylmethyl)NoYes
315-37-7Androst-4-en-3-one, 17-[(1-oxoheptyl)oxy]-, (17β)-NoYes
469-61-41H-3a,7-Methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-, [3R-(3α,3aβ,7β,8aα)]-NoYes
470-40-6Cyclopropa[d]naphthalene, 1,1a,4,4a,5,6,7,8-octahydro-2,4a,8,8-tetramethyl-, [1aS-(1aα,4aβ ,8aR)]-YesYes
471-53-4Olean-12-en-29-oic acid, 3-hydroxy-11-oxo, (3β,20β) NoYes
489-40-71H-Cycloprop[e]azulene, 1a,2,3,4,4a,5,6,7b-octahydro-1,1,4,7-tetramethyl-, [1aR-(1aα,4α,4aß,7bα)]-YesYes
489-84-9Azulene, 1,4-dimethyl-7-(1-methylethyl)-NoYes
489-86-15-Azulenemethanol, 1,2,3,4,5,6,7,8-octahydro- α,α,3,8-tetramethyl-, [3S-(3α,5α,8α)]-NoYes
495-62-5Cyclohexene, 4-(1,5-dimethyl-4-hexenylidene)-1-methyl-YesYes
502-72-7CyclopentadecanoneNoYes
506-61-6Argentate(1-), bis(cyano-C)-, potassiumYesYes
506-87-6Carbonic acid, diammonium saltNoYes
513-86-02-Butanone, 3-hydroxy-NoYes
514-51-24,7-Methanoazulene, 1,2,3,4,5,6,7,8-octahydro-1,4,9,9-tetramethyl-, [1S-(1α,4α,7α)]-NoYes
527-09-3Copper, bis(D-gluconato-O1,O2)-NoYes
541-91-3Cyclopentadecanone, 3-methyl-YesYes
542-46-19-Cycloheptadecen-1-one, (Z)-NoYes
546-28-11H-3a,7-Methanoazulene, octahydro-3,8,8-trimethyl-6-methylene-, [3R-(3α,3aß,7ß,8aα)]-YesYes
546-89-4Acetic acid, lithium saltNoYes
563-68-8Acetic acid, thallium(1+) salt YesNo
596-03-2Spiro[isobenzofuran-1(3H),9 '-[9H]xanthen]-3-one, 4 ',5 '-dibromo-3 ',6 '-dihydroxy-NoYes
623-42-7Butanoic acid, methyl esterNoYes
632-51-9Benzene, 1,1 ',1 ' ',1 ' ' '-(1,2-ethenediylidene)tetrakis-NoYes
639-99-6Cyclohexanemethanol, 4-ethenyl-α,α ,4-trimethyl-3-(1-methylethenyl)-, [1R-(1α,3α,4ß)]-YesYes
647-42-71-Octanol, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-NoYes
1113-21-91,6,10,14-Hexadecatetraen-3-ol, 3,7,11,15-tetramethyl-, (E,E)-YesYes
1139-30-65-Oxatricyclo[8.2.0.04,6]dodecane, 4,12,12-trimethyl-9-methylene-, [1R-(1R,4R,6R,10S)]-NoYes
1304-85-4Bismuth hydroxide nitrate oxide (Bi5(OH)9(NO3)4O)NoYes
1317-25-5Aluminum, chloro[(2,5-dioxo-4-imidazolidinyl)ureato]tetrahydroxydi-NoYes
1328-04-7C.I. Pigment Violet 5:1NoYes
1328-51-4C.I. Solvent Blue 38NoYes
1334-78-7Benzaldehyde, methyl-NoYes
1335-94-0IroneNoYes
1345-24-0C.I. Pigment Red 109NoYes
1533-45-5Benzoxazole, 2,2 '-(1,2-ethenediyldi-4,1-phenylene)bis-YesYes
1740-19-81-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1α,4aβ,10aα)]-YesYes
2379-79-5Anthra[2,3-d]oxazole-5,10-dione, 2-(1-amino-9,10-dihydro-9,10-dioxo-2-anthracenyl)-NoYes
2387-03-31-Naphthalenecarboxaldehyde, 2-hydroxy-, [(2-hydroxy-1-naphthalenyl)methylene]hydrazoneNoYes
2398-96-1Carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl esterNoYes
2422-91-5Benzene, 1,1 ' ,1" -methylidynetris[4-isocyanato-NoYes
2478-20-81H-Benz[de]isoquinoline-1,3(2H)-dione, 6-amino-2-(2,4-dimethylphenyl)-NoYes
3407-42-9Cyclohexanol, 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-NoYes
3426-43-5Benzenesulfonic acid, 2,2 '-(1,2-ethenediyl)bis[5-[[4-methoxy-6-(phenylamino)-1,3,5-triazin-2-yl]amino]-, disodium saltNoYes
3738-00-9Naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-NoYes
4051-63-2[1,1 '-Bianthracene]-9,9 ',10,10 '-tetrone, 4,4 '-diamino-YesYes
4378-61-4Dibenzo[def,mno]chrysene-6,12-dione, 4,10-dibromo-YesYes
4572-09-2Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-, compd. with (2,5-dioxo-4-imidazolidinyl)urea (1:1)NoYes
4630-07-3Naphthalene, 1,2,3,5,6,7,8,8a-octahydro- 1,8a-dimethyl-7-(1-methylethenyl)-, [1R-(1α,7ß,8aα)]-YesYes
4979-32-22-Benzothiazolesulfenamide, N,N-dicyclohexyl- YesNo
5089-22-5Benzoxazole, 2,2 ' -(1,4-naphthalenediyl)bisYesYes
5579-81-7Aluminum, [(2,5-dioxo-4-imidazolidinyl)ureato]dihydroxy-NoYes
6858-49-7Propanedinitrile, [[4-[ethyl[2-[[(phenylamino)carbonyl]oxy]ethyl]amino]-2-methylphenyl]methylene]-YesNo
7425-14-1Hexanoic acid, 2-ethyl-, 2-ethylhexyl esterNoYes
7447-39-4Copper chloride (CuCl2)NoYes
7758-89-6Copper chloride (CuCl)NoYes
7773-06-0Sulfamic acid, monoammonium saltNoYes
7779-30-81-Penten-3-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-NoYes
7779-50-2Oxacycloheptadec-7-en-2-oneNoYes
7783-90-6Silver chloride (AgCl)YesYes
7784-25-0Sulfuric acid, aluminum ammonium salt (2:1:1)NoYes
7785-23-1Silver bromide (AgBr)NoYes
7791-12-0Thallium chloride (TlCl)YesNo
7798-23-4Phosphoric acid, copper(2++) salt (2:3)NoYes
8000-27-9Oils, cedarwoodNoYes
8000-46-2Oils, geraniumNoYes
8000-73-5Carbonic acid, monoammonium salt, mixt. with carbamic acid monoammonium saltNoYes
8001-04-5MusksNoYes
8001-61-4Balsams, copaibaNoYes
8002-65-1Margosa oilNoYes
8006-78-8Oils, bayNoYes
8006-87-9Oils, sandalwoodNoYes
8007-01-0Oils, roseNoYes
8007-02-1Oils, lemongrassNoYes
8007-08-7Oils, GingerNoYes
8008-31-9Oils, mandarinNoYes
8008-52-4Oils, corianderNoYes
8008-93-3Oils, wormwoodNoYes
8011-96-9Calamine (pharmaceutical preparation)NoYes
8013-10-3Oils, cadeNoYes
8014-19-5Oils, palmarosaNoYes
8015-77-8Oils, bois de roseNoYes
8016-37-3Oils, myrrhNoYes
8016-85-1Oils, tangerineNoYes
8016-88-4Oils, tarragonNoYes
8021-28-1Oils, firNoYes
8021-39-4Creosote, woodNoYes
8022-56-8Oils, sageNoYes
8022-96-6Oils, JasmineNoYes
8023-75-4Oils, jonquilNoYes
8024-05-3Oils, tuberoseNoYes
8024-06-4Oils, vanillaNoYes
8024-08-6Oils, violetNoYes
8024-43-9Perfumes and Essences, jasminNoYes
8031-03-6Oils, mimosaNoYes
8046-19-3Storax (balsam)NoYes
10043-67-1Sulfuric acid, aluminum potassium salt (2:1:1)NoYes
10099-58-8Lanthanum chloride (LaCl3)NoYes
10294-26-5Sulfuric acid, disilver(1+)YesYes
10361-44-1Nitric acid, bismuth(3+) saltYesNo
11006-34-1Cuprate(3-), [18-carboxy-20-(carboxymethyl)-8-ethenyl-13-ethyl-2,3-dihydro-3,7,12,17-tetramethyl-21H,23H-porphine-2-propanoato(5-)-N21,N22,N23,N24]-, trisodium, [SP-4-2-(2S-trans)]-NoYes
11103-57-4Vitamin A NoYes
11103-86-9Chromate(1-), hydroxyoctaoxodizincatedi-, potassiumYesNo
12004-11-4Aluminate(8-), hexaoxo[sulfato(2-)]di-, calcium (1:4)NoYes
12005-57-1Aluminate (Al14O3324-), calcium (1:12)NoYes
12008-21-8Lanthanum boride (LaB6), (OC-6-11)YesNo
12036-32-7Praseodymium oxide (Pr2O3)YesYes
12042-78-3Aluminate (AlO33-)), calcium (2:3)NoYes
12060-59-2Titanate (TiO32-), strontium (1:1)NoYes
12068-03-0Benzenesulfonic acid, methyl-, sodium saltNoYes
12135-76-1Ammonium sulfide ((NH4)2S)NoYes
12224-98-5Xanthylium, 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-, molybdatetungstatephosphateNoYes
12442-27-2Cadmium zinc sulfide ((Cd,Zn)S)NoYes
13082-47-8Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, hydroxideYesNo
13680-35-8Benzenamine, 4,4 '-methylenebis[2,6-diethyl-NoYes
13746-66-2Ferrate(3-), hexakis(cyano-c)-, tripotassium, (oc-6-11)-YesYes
13826-83-0Borate(1-), tetrafluoro-, ammoniumNoYes
13943-58-3Ferrate(4-), hexakis(cyano-C)-, tetrapotassium, (OC-6-11)-NoYes
13967-50-5Aurate(1-), bis(cyano-C)-, potassiumNoYes
14221-47-7Ferrate(3-), tris[ethanedioato(2-)-O,O']-, triammonium, (OC-6-11)-NoYes
14233-37-59,10-Anthracenedione, 1,4-bis[(1-methylethyl)amino]-NoYes
14476-25-6Smithsonite (Zn(CO3NoYes
15647-08-2Phosphorous acid, 2-ethylhexyl diphenyl esterYesYes
15791-78-39,10-Anthracenedione, 1,8-dihydroxy-4-[[4-(2-hydroxyethyl)phenyl]amino]-5-nitro-NoYes
16283-36-6Zinc, bis(2-hydroxybenzoato-O1,O2)-, (T-4)-NoYes
16919-27-0Titanate(2-), hexafluoro-, dipotassium, (OC-6-11)-NoYes
17418-58-59,10-Anthracenedione, 1-amino-4-hydroxy-2-phenoxy-NoYes
17627-44-0Cyclohexene, 4-(1,5-dimethyl-1,4-hexadienyl)-1-methyl-YesYes
18917-89-0Magnesium, bis(2-hydroxybenzoato-O¹,O²)-, (T-4)-NoYes
19210-06-1Phosphorodithioic acid, zinc saltNoYes
19286-75-09,10-Anthracenedione, 1-hydroxy-4-(phenylamino)-NoYes
19720-45-79,10-Anthracenedione, 1,4-bis[(2-methylpropyl)amino]-YesNo
20338-08-3Titanium hydroxide (Ti(OH)4),(T-4)-NoYes
20461-54-5IodineNoYes
20667-12-3Silver oxide (Ag2O)YesYes
21260-46-8Bismuth, tris(dimethylcarbamodithioato-S,S ')-, (OC-6-11)-YesNo
21564-17-0Thiocyanic acid, (2-benzothiazolylthio)methyl esterNoYes
22221-10-9Hexanoic acid, 2-ethyl-, copper saltNoYes
22451-73-65-Azulenemethanol, 1,2,3,3a,4,5,6,7-octahydro- α,α,3,8-tetramethyl-, [3S-(3α,3aß,5α)]-NoYes
25428-43-73-Cyclohexene-1-methanol, α,4-dimethyl-α-(4-methyl-3-pentenyl)-, (R,R)-(±)-NoYes
25869-98-1Ferrate(4-), hexakis(cyano-C)-, iron(3++) potassium (1:1:1), (OC-6-11)-NoYes
26266-77-31-Phenanthrenemethanol, dodecahydro-1,4a-dimethyl-7-(1-methylethyl)-NoYes
26694-69-9Xanthylium, 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-, ethyl sulfateNoYes
28173-59-3Carbonic acid, 2-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthracenyl)oxy]ethyl phenyl ester4YesNo
28645-51-4Oxacycloheptadec-10-en-2-oneYesYes
28768-32-3Oxiranemethanamine, N,N ' -(methylenedi-4,1-phenylene)bis[N-(oxiranylmethyl)-YesNo
28984-69-24,4(5H)-Oxazoledimethanol, 2-(heptadecenyl)-YesYes
29350-73-0Naphthalene, decahydro-1,6-dimethyl-4-(1-methylethyl)-, [1S-(1α,4α,4aα,6α,8aβ)]-, didehydro deriv.NoYes
30745-55-2Aluminum, bis(2-ethylhexanoato-O)hydroxyl-YesYes
31135-57-61H-Benzimidazolesulfonic acid, 2-heptadecyl-1-[(sulfophenyl)methyl]-, disodium saltYesNo
31142-56-01,2,3-Propanetricarboxylic acid, 2-hydroxy-, aluminum saltNoYes
34364-26-6Neodecanoic acid, bismuth(3+) saltYesYes
37310-83-19-Octadecen-1-ol, (Z)-, phosphateNoYes
37609-25-95-Cyclohexadecen-1-oneYesYes
37677-14-83-Cyclohexene-1-carboxaldehyde, 4-(4-methyl-3-pentenyl)-YesYes
42373-04-6Thiazolium, 3-methyl-2-[(1-methyl-2-phenyl-1H-indol-3-yl)azo]-, chlorideNoYes
43048-08-42-Propenoic acid, 2-methyl-, (octahydro-4,7-methano-1H-indene-5,?-diyl)bis(methylene) esterNoYes
49663-84-5Zinc chromate hydroxide (Zn5(CrO4)(OH)8)NoYes
50922-29-7Chromium zinc oxideYesYes
52474-60-93-Cyclohexene-1-carboxaldehyde, 1-methyl-3-(4-methyl-3-petenyl)-YesYes
52475-86-23-Cyclohexene-1-carboxaldehyde, 1-methyl-4-(4-methyl-3-pentenyl)-NoYes
56797-01-4Hexanoic acid, 2-ethyl-, cerium(3++) saltNoYes
58713-21-61,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane, hydrochlorideNoYes
59056-62-12,3b-Methano-3bH-cyclopenta[1,3]cyclopropa[1,2]benzene-4-methanol, octahydro-7,7,8,8-tetramethyl-, acetateNoYes
61788-72-5Fatty acids, tall-oil, epoxidized, octyl estersNoYes
61789-85-3Sulfonic acids, petroleumNoYes
61791-34-2Onium compounds, morpholinium, 4-ethyl-4-soya alkyl, Et sulfatesNoYes
62973-79-9Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, molybdatesilicateYesYes
63449-68-32-Naphthalenol, 2-aminobenzoyl esterNoYes
65113-99-73-Cyclopentene-1-butanol, α,ß,2,2,3-pentamethyl--NoYes
65405-84-7Cyclohexenebutanal, α,2,2,6-tetramethyl-NoYes
66068-84-6Cyclohexanol, 4-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-NoYes
66072-38-6Oxirane, 2,2 ',2 ' '-[methylidynetris(phenyleneoxymethylene)]tris-NoYes
66327-54-63-Cyclohexene-1-carboxaldehyde, 1-methyl-4-(4-methylpentyl)-NoYes
67633-57-21H-Imidazolium, 1-ethyl-4,5-dihydro-1-(2-hydroxyethyl)-2-isoheptadecyl-, ethyl sulfate (salt)NoYes
68082-35-9Fatty acids, soya, epoxidized, Me estersNoYes
68084-48-0Neodecanoic acid, copper(2+) saltYesYes
68186-14-1Resin acids and Rosin acids, Me estersNoYes
68187-12-2C.I. Pigment Red 233NoYes
68475-76-3Flue dust, portland cementNoYes
68476-03-9Fatty acids, montan-waxNoYes
68551-42-8Fatty acids, C6-19-branched, manganese saltsNoYes
68603-15-6Alcohols, C6-12NoYes
68604-99-9Fatty acids, C18-unsatd., phosphatesNoYes
68608-32-2Terpenes and Terpenoids, cedarwood-oilNoYes
68647-58-5Aluminum, benzoate hydrogenated tallow fatty acid iso-Pr alc. ComplexesNoYes
68784-17-8Isooctadecanoic acid, reaction products with tetraethylenepentamineNoYes
68877-29-2Cyclohexanol, (1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-YesYes
68890-99-3Benzene, mono-C10-16-alkyl derivs.NoYes
68916-97-2Oils, horehoundNoYes
68917-29-3Terpenes and Terpenoids, clove-oilYesYes
68917-65-7Terpenes and Terpenoids, vetiver-oilNoYes
68917-75-9Oils, wintergreenYesYes
68952-35-2Tar acids, cresylic, Ph phosphatesNoYes
68966-38-11H-Imidazole-1-ethanol, 4,5-dihydro-2-isoheptadecyl-NoYes
68990-83-0Oils, cedarwood, TexanYesYes
70225-05-71,2,4-Benzenetricarboxylic acid, mixed branched tridecyl and isodecyl estersNoYes
70288-86-7IvermectinYesNo
70788-30-6Cyclohexanepropanol, 2,2,6-trimethyl-α-propyl-YesYes
70833-37-3Nickel, bis(3-amino-4,5,6,7-tetrachloro-1H-isoindol-1-one oximato-N2,O1)-NoYes
70955-71-4Phenol, 2-methoxy-, reaction products with 2,2-dimethyl-3-methylenebicyclo[2.2.1]heptane, hydrogenatedNoYes
71159-90-53-Cyclohexene-1-methanethiol, α,α,4-trimethyl-NoYes
72102-40-01-Propanaminium, 3-amino-N-ethyl-N,N-dimethyl-, N-lanolin acyl derivs., Et sulfatesNoYes
72391-24-3Benzenesulfonic acid, [[(chloroacetyl)amino]methyl][4-[[4-(cyclohexylamino)-9,10-dihydro-9,10-dioxo-1-anthracenyl]amino]phenoxy]methyl-, monosodium saltNoYes
73138-82-6Resin acids and Rosin acidsNoYes
73984-93-71,3,4-Thiadiazole-2(3H)-thione, 5-(tert-dodecyldithio)-NoYes
84012-15-7Birch, Betula alba, ext.NoYes
84082-54-2Ivy, Hedera helix, ext.NoYes
84696-24-2Lotus corniculatus, ext.NoYes
84961-67-1Verbena officinalis, ext.NoYes
90028-66-3Evening primrose, Oenothera biennis, ext.NoYes
90045-36-6Ginkgo biloba, ext.NoYes
90045-38-8Ginseng, Panax quinquefolium, ext.NoYes
90367-27-4Ethanol, 2,2 '-[[3-[(2-hydroxyethyl)amino]propyl]imino]bis-, N-tallow alkyl derivs.NoYes
90459-62-4Octadecanoic acid, reaction products with diethylenetriamine, di-Me sulfate-quaternizedNoYes
107898-54-44-Penten-2-ol, 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-NoYes
111174-63-1Protein hydrolyzates, leather, reaction products with isostearoyl chlorideNoYes
115340-80-21-Propanaminium, 3-amino-N-ethyl-N,N-dimethyl-, N-wheat-oil acyl derivs., Et sulfatesNoYes
120547-52-6Oxirane, mono[(C12-13alkyloxy)methyl] derivs.NoYes
129828-23-5Fatty acids, tall-oil, reaction products with Bu phenylmethyl phthalate, 2-(dimethylamino)ethanol, morpholine and overbased calcium petroleum sulfonatesNoYes
164288-52-2Cork tree, Phellodendron amurense, ext.NoYes

aChemical Abstracts Service Registry Number

Appendix C: Substances identified as not meeting the criteria under section 64 of the Canadian Environmental Protection Act, 1999 (CEPA 1999)

Substances identified as not meeting the criteria under section 64 of CEPA 1999
CAS RNaDomestic Substances List namePotential SNAc candidate (and basis for concern)Additional information on use*
50-41-9Ethanamine, 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)Not applicablePharmaceutical
50-50-0Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-benzoateNot applicableNot applicable
50-52-210H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-Not applicablePharmaceutical
50-53-310H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-Not applicablePharmaceutical
51-28-5Phenol, 2,4-dinitro-Not applicableHistorical Pesticide Active
51-48-9L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-Yes (Ecological)Pharmaceutical
52-86-81-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-Not applicablePharmaceutical
57-12-5CyanideNot applicableNot applicable
60-87-710H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-Not applicablePharmaceutical
60-99-110H-Phenothiazine-10-propanamine, 2-methoxy-N,N,β-trimethyl-, (βR)-Not applicablePharmaceutical
70-30-4Phenol, 2,2 '-methylenebis[3,4,6-trichloro-Not applicablePharmaceutical
72-33-319-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy-, (17α)-Not applicableNot applicable
72-69-51-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-Not applicablePharmaceutical
79-54-91-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,9,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1α,4aβ,4bα,10aα)]-Not applicableNot applicable
80-10-4Silane, dichlorodiphenyl-Not applicableNot applicable
83-66-9Benzene, 1-(1,1-dimethylethyl)-2-methoxy-4-methyl-3,5-dinitro-Not applicableFragrance/ Flavourant
84-96-810H-Phenothiazine-10-propanamine, N,N,β-trimethyl-Not applicablePharmaceutical
85-00-7Dipyrido[1,2-a:2 ',1 '-c]pyrazinediium, 6,7-dihydro-, dibromideNot applicableNot applicable
88-58-41,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-Not applicableNot applicable
89-47-4Butanoic acid, 3-methyl-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, (1α,2β,5α)-Not applicableNot applicable
91-50-9Benzoic acid, 2-[[2-methyl-3-[4-(1-methylethyl)phenyl]propylidene]amino]-, methyl esterNot applicableFragrance/ Flavourant
95-19-21H-Imidazole-1-ethanol, 2-heptadecyl-4,5-dihydro-Not applicableNot applicable
95-73-8Benzene, 2,4-dichloro-1-methyl-Not applicableNot applicable
97-23-4Phenol, 2,2 '-methylenebis[4-chloro-Not applicableHistorical Pesticide Active
98-95-3Benzene, nitro-Yes (Human Health)Not applicable
99-82-1Cyclohexane, 1-methyl-4-(1-methylethyl)-Not applicableNot applicable
100-46-9BenzenemethanamineNot applicableNot applicable
100-99-2Aluminum, tris(2-methylpropyl)-Not applicableNot applicable
101-65-5Carbamic acid, (methylenedi-4,1-phenylene)bis-, diphenyl esterYes (Ecological)Not applicable
105-58-8Carbonic acid, diethyl esterNot applicableFragrance/ Flavourant
109-72-8Lithium, butyl-Not applicableNot applicable
111-83-1Octane, 1-bromo-Not applicableNot applicable
112-29-8Decane, 1-bromo-Not applicableNot applicable
112-52-7Dodecane, 1-chloro-Not applicableNot applicable
115-71-92-Penten-1-ol, 5-(2,3-dimethyltricyclo[2.2.1.02,6]hept-3-yl)-2-methyl-, stereoisomerNot applicableFragrance/ Flavourant
118-65-0Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, [1R-(1R,4Z,9S)]-Not applicableFragrance/ Flavourant
120-83-2Phenol, 2,4-dichloro-Not applicableNot applicable
121-21-1Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, 2-methyl-4-oxo-3-(2,4-pentadienyl)-2-cyclopenten-1-yl ester, [1R-[1α[S(Z)],3β]]-Not applicableNot applicable
123-69-3Oxacycloheptadec-8-en-2-one, (Z)-Yes (Ecological)Formulant
128-66-5Dibenzo[b,def]chrysene-7,14-dioneNot applicableNot applicable
129-09-9Anthra[2,1-d:6,5-d ']bisthiazole-6,12-dione, 2,8-diphenyl-Not applicableNot applicable
129-73-7Benzenamine, 4,4 '-(phenylmethylene)bis[N,N-dimethyl-Not applicableNot applicable
133-66-4Benzenesulfonic acid, 2,2 '-(1,2-ethenediyl)bis[5-[[4,6-bis(phenylamino)-1,3,5-triazin-2-yl]amino]-, disodium saltNot applicableNot applicable
135-88-62-Naphthalenamine, N-phenyl-Yes (Human Health)Not applicable
140-29-4BenzeneacetonitrileNot applicableNot applicable
140-41-0Acetic acid, trichloro-, compd. with N '-(4-chlorophenyl)-N,N-dimethylurea (1:1)Yes (Human Health)Not applicable
140-73-81,6-Hexanediamine, N,N '-bis(3-phenyl-2-propenylidene)-Not applicableNot applicable
141-38-8Oxiraneoctanoic acid, 3-octyl-, 2-ethylhexyl esterNot applicableNot applicable
149-11-1Hexanoic acid, 2-ethyl-, copper(2+) saltNot applicableNot applicable
151-50-8Potassium cyanide (K(CN))Not applicablePharmaceutical
297-76-719-Norpregn-4-en-20-yne-3,17-diol, diacetate, (3β,17α)-Not applicablePharmaceutical
302-79-4Retinoic acidYes (Ecological)Pharmaceutical
357-57-3Strychnidin-10-one, 2,3-dimethoxy-Not applicableNot applicable
360-70-3Estr-4-en-3-one, 17-[(1-oxodecyl)oxy]-, (17β)-Not applicableNot applicable
420-04-2CyanamideNot applicableHistorical Pesticide Active
485-19-87-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-, (1S)-Not applicableNot applicable
506-64-9Silver cyanide (Ag(CN))Not applicableNot applicable
506-68-3Cyanogen bromide ((CN)Br)Not applicableNot applicable
514-10-31-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1α,4aβ,4bα,10aα)]-Not applicableNot applicable
519-73-3Benzene, 1,1 ',1 ' '-methylidynetris-Not applicableNot applicable
522-00-910H-Phenothiazine-10-ethanamine, N,N-diethyl-α-methyl-Not applicablePharmaceutical
537-00-8Acetic acid, cerium(3+) saltNot applicableNot applicable
537-01-9Carbonic acid, cerium(3+) salt (3:2)Not applicableNot applicable
541-09-3Uranium, bis(acetato-O)dioxo-Not applicableNot applicable
542-76-7Propanenitrile, 3-chloro-Not applicableNot applicable
542-83-6Cadmium cyanide (Cd(CN)2)Not applicableNot applicable
544-19-4Formic acid, copper(2+) saltNot applicableNot applicable
544-92-3Copper cyanide (Cu(CN))Not applicableNot applicable
556-61-6Methane, isothiocyanato-Not applicableHistorical Pesticide Active
560-88-3Benzoic acid, 2-hydroxy-, 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, endo-Not applicableNot applicable
563-63-3Acetic acid, silver(1+) saltNot applicableNot applicable
587-26-8Carbonic acid, lanthanum(3+) salt (3:2)Not applicablePharmaceutical
590-28-3Cyanic acid, potassium saltNot applicableNot applicable
592-01-8Calcium cyanide (Ca(CN)2)Not applicableHistorical Pesticide Active
592-82-5Butane, 1-isothiocyanato-Not applicableFragrance/ Flavourant
592-85-8Thiocyanic acid, mercury(2+) saltNot applicableNot applicable
605-01-6Benzene, pentaethyl-Not applicableNot applicable
622-20-8Benzene, 1,1 '-[1,2-ethanediylbis(thio)]bis-Not applicableNot applicable
739-71-95H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,β-trimethyl-Not applicableNot applicable
751-94-029-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, monosodium salt, (3α,4α,8α,9β,11α,13α, -14β,16β,17Z)-Yes (Ecological)Pharmaceutical
814-91-5Ethanedioic acid, copper(2+) salt (1:1)Not applicableNot applicable
917-70-4Acetic acid, lanthanum(3+) saltNot applicableNot applicable
950-33-4Cyclododecane, 1,1-dimethoxy-Not applicableFragrance/ Flavourant
969-33-5Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochlorideNot applicableNot applicable
979-32-8Estra-1,3,5(10)-triene-3,17-diol (17β)-, 17-pentanoateNot applicablePharmaceutical
1025-15-61,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tri-2-propenyl-Not applicableNot applicable
1096-48-69,10-Anthracenedione, 1-(cyclohexylamino)-Not applicableNot applicable
1120-44-19-Octadecenoic acid (Z)-, copper(2+) saltNot applicableNot applicable
1135-66-62H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S)-Not applicableFragrance/ Flavourant
1172-18-52H-1,4-Benzodiazepin-2-one, 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-, dihydrochlorideNot applicablePharmaceutical
1209-61-65-Oxatricyclo[8.2.0.04,6]dodecane, 4,9,12,12-tetramethyl-Not applicableFragrance/ Flavourant
1299-86-1Aluminum carbide (Al4C3)Not applicableNot applicable
1313-97-9Neodymium oxide (Nd2O3)Not applicableNot applicable
1314-20-1Thorium oxide (ThO2)Yes (Human Health)Not applicable
1314-61-0Tantalum oxide (Ta2O5)Not applicableNot applicable
1324-58-9Diindolo[3,2-b:3 ',2 '-m]triphenodioxazinetrisulfonic acid, 8,18-dichloro-5,15-diethyl-5,15-dihydro-, trisodium saltNot applicableNot applicable
1329-99-3Cyclohexane, 1-methyl-4-(1-methylethyl)-, tetradehydro deriv.Not applicableFormulant
1331-61-9Benzenesulfonic acid, dodecyl-, ammonium saltNot applicableNot applicable
1332-14-5Sulfuric acid, copper(2+) salt, basicNot applicableNot applicable
1332-65-6Copper chloride hydroxide (Cu2Cl(OH)3)Not applicableNot applicable
1344-67-8Copper chlorideNot applicableNot applicable
1405-92-11H-3a,7-Methanoazulene-6-methanol, 2,3,4,7,8,8a-hexahydro-3,8,8-trimethyl-, acetate, [3R-(3α,3aβ,7β,8aα)]-Not applicableFormulant
1446-61-31-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1α,4aβ,10aα)]-Not applicableNot applicable
1470-61-7Silver, (diethylcarbamodithioato-S,S ')-Not applicableNot applicable
1478-61-1Phenol, 4,4 '-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis-Not applicableNot applicable
1622-61-31-Pyrrolidinepropanol, α-cyclohexyl-α-phenyl-, hydrochlorideNot applicablePharmaceutical
1746-23-2Benzene, 1-(1,1-dimethylethyl)-4-ethenyl-Not applicableNot applicable
1796-92-5Benzoic acid, 5-[(3-carboxy-5-methyl-4-oxo-2,5-cyclohexadien-1-ylidene)(2,6-dichlorophenyl)methyl]-2-hydroxy-3-methyl-, disodium saltYes (Ecological)Not applicable
1799-84-42-Propenoic acid, 2-methyl-, 3,3,4,4,5,5,6,6,6-nonafluorohexyl esterNot applicableNot applicable
1817-68-1Phenol, 4-methyl-2,6-bis(1-phenylethyl)-Not applicableNot applicable
1922-67-41H-Naphtho[2,3-c]pyran, 3,4,6,7,8,9-hexahydro-4,6,6,9,9-pentamethyl-Not applicableNot applicable
2026-24-61-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, acetate, [1R-(1α,4aβ,10aα)]-Not applicableHistorical Pesticide Active
2144-53-82-Propenoic acid, 2-methyl-, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl esterNot applicableNot applicable
2162-73-4Benzene, 2,4-diisocyanate-1,3,5-tris(1-methylethyl)-Not applicableNot applicable
2386-52-9Methanesulfonic acid, silver(1+) saltNot applicableNot applicable
2451-84-5Hexanedioic acid, bis(phenylmethyl) esterNot applicableNot applicable
2611-00-93-Cyclohexene-1-carboxylic acid, 3-cyclohexen-1-ylmethyl esterNot applicableNot applicable
2944-30-19,10-Anthracenedione, 1,4-bis[(4-methoxyphenyl)amino]-Yes (Ecological)Not applicable
2966-50-9Acetic acid, trifluoro-, silver(1+) saltNot applicableNot applicable
3042-75-9Benzeneacetic acid, α-chloro-α-phenyl-, 2-(dimethylamino)ethyl ester, hydrochlorideNot applicableNot applicable
3089-55-2Hexanedioic acid, octyl phenylmethyl esterNot applicableNot applicable
3251-84-1Methanaminium, N-[4-[[4-(cyclohexylamino)-1-naphthalenyl][4-(dimethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chlorideNot applicableNot applicable
3253-39-22-Propenoic acid, 2-methyl-, (1-methylethylidene)di-4,1-phenylene esterNot applicableNot applicable
3315-16-0Cyanic acid, silver(1+) saltNot applicableNot applicable
3333-62-82H-1-Benzopyran-2-one, 7-(2H-naphtho[1,2-d]triazol-2-yl)-3-phenyl-Not applicableNot applicable
3444-14-2Carbonic acid, copper(1+) saltNot applicableNot applicable
3526-75-85-Azulenemethanol, decahydro-α,α,3,8-tetramethyl-, [3S-(3α,3aβ,5α,8α,8aβ)]-Not applicableFragrance/ Flavourant
3564-75-85H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,β-trimethyl-, (-)-Not applicableNot applicable
3572-52-91,1'-Biphenyl -3-carboxylic acid, 2-hydroxy-, 2-(diethylamino)ethyl esterNot applicableNot applicable
3688-79-77H-Benz[de]anthracen-7-one, 3-methoxy-Not applicableNot applicable
3860-63-79,10-Anthracenedione, 1,5-dihydroxy-4,8-bis(methylamino)-Not applicableNot applicable
3910-35-81H-Indene, 2,3-dihydro-1,1,3-trimethyl-3-phenyl-Yes (Ecological)Formulant
4091-99-0Benzoic acid, 2-[3,6-bis(acetyloxy)-2,7-dichloro-9H-xanthen-9-yl]-Yes (Ecological)Not applicable
4105-12-8Cyclohexanol, 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-, [1α,2α(1S,3S),4α,6α]-Not applicableFragrance/ Flavourant
4111-54-02-Propanamine, N-(1-methylethyl)-, lithium saltNot applicableNot applicable
4196-86-51,3-Propanediol, 2,2-bis[(benzoyloxy)methyl]-, dibenzoateNot applicableNot applicable
4203-77-4[3,3 '-Bianthra[1,9-cd]pyrazole]-6,6 '(1H,1 'H)-dione, 1,1 '-diethyl-Not applicableNot applicable
4216-01-77H-Benzo[e]perimidine-4-carboxamide, N-(9,10-dihydro-9,10-dioxo-1-anthracenyl)-7-oxo-Not applicableNot applicable
4270-70-6Sulfonium, triphenyl-, chlorideNot applicableNot applicable
4330-99-810H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)Not applicablePharmaceutical
4424-87-7Benzo[1,2-c:4,5-c ']diacridine-6,9,15,18(5H,14H)-tetroneNot applicableNot applicable
4499-91-6Docosanoic acid, lithium saltNot applicableNot applicable
4702-65-29,10-Anthracenedione, 4,8-diamino-1,5-dihydroxy-2-(4-hydroxy-3-methylphenyl)-Not applicableNot applicable
4759-48-2Retinoic acid, 13-cis-Not applicablePharmaceutical
4802-20-4Cyclohexaneethanethiol, 3-mercapto-β,4-dimethyl-Not applicableFragrance/ Flavourant
5284-79-7Cyclohexanone, 2,6-bis[(4-azidophenyl)methylene]-4-methyl-Yes (Ecological)Not applicable
5875-45-6Phenol, 2,5-bis(1,1-dimethylethyl)-Not applicableNot applicable
6028-47-32-Pentanol, 4-methyl-, hydrogen phosphorodithioateNot applicableNot applicable
6070-16-2Hexanoic acid, 5-methyl-2-(1-methylethyl)cyclohexyl ester, (1α,2β,5α)-Not applicableFragrance/ Flavourant
6130-43-4Heptanoic acid, tridecafluoro-, ammonium saltNot applicableNot applicable
6144-04-3Benzene, (1-methylethenyl)-, dimerNot applicableNot applicable
6196-94-7Benzene, 1-ethyl-4-(1-phenylethyl)-Not applicableNot applicable
6196-95-8Benzene, 1,2-dimethyl-4-(1-phenylethyl)-Not applicableNot applicable
6221-92-7Cyclododecanol, acetateNot applicableFragrance/ Flavourant
6252-76-2Xanthylium, 9-(2-carboxyphenyl)-3-[(2-methylphenyl)amino]-6-[(2-methyl-4-sulfophenyl)amino]-, hydroxide, inner salt, monosodium saltNot applicableNot applicable
6291-95-81,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2-methyl-2-propenyl)-Not applicableNot applicable
6408-57-7Benzenesulfonic acid, 2,2 '-[(9,10-dihydro-9,10-dioxo-1,4-anthracenediyl)diimino]bis[5-butyl-, disodium saltNot applicableNot applicable
6661-40-1Benzenesulfonic acid, 2-ethoxy-5-[[4-[[4-[(4-ethoxy-3-sulfophenyl)amino]phenyl](1-methyl-2-phenyl-1H-indol-3-yl)methylene]-2,5-cyclohexadien-1-ylidene]amino]-, monosodium saltNot applicableNot applicable
6804-07-5Hydrazinecarboxylic acid, [(1,4-dioxido-2-quinoxalinyl)methylene]-, methyl esterYes (Human Health)Not applicable
6990-06-329-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-Not applicablePharmaceutical
7098-08-09,10-Anthracenedione, 4,8-diamino-1,5-dihydroxy-2-(4-hydroxyphenyl)-Not applicableNot applicable
7158-25-04,9:5,8-Dimethano-1H-benz[f]indene, 3a,4,4a,5,8,8a,9,9a-octahydro-Not applicableFragrance/ Flavourant
7360-44-3Aluminum, (acetato-O)dihydroxy-Not applicableNot applicable
7435-02-1Octanoic acid, cerium saltNot applicableNot applicable
7439-15-8Benzene, 1-ethyl-4-(2-phenylethyl)-Not applicableNot applicable
7439-91-0LanthanumNot applicablePharmaceutical
7439-94-3LutetiumNot applicableNot applicable
7440-45-1CeriumNot applicableNot applicable
7440-65-5YttriumNot applicableNot applicable
7488-49-52,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, (2R,6R,11R)-Not applicableNot applicable
7647-10-1Palladium chloride (PdCl2)Not applicableNot applicable
7717-62-6Benzeneacetic acid, 1-phenyl-1,2-ethanediyl esterYes (Ecological)Not applicable
7758-88-5Cerium fluoride (CeF3)Not applicableNot applicable
7774-29-0Mercury iodide (HgI2)Yes (Ecological)Not applicable
7782-39-0DeuteriumNot applicableNot applicable
7783-33-7Mercurate(2-), tetraiodo-, dipotassium, (T-4)-Not applicableNot applicable
7783-49-5Zinc fluoride (ZnF2)Not applicableNot applicable
7783-70-2Antimony fluoride (SbF5)Not applicableNot applicable
7783-86-0Iron iodide (FeI2)Not applicableNot applicable
7783-96-2Silver iodide (AgI)Not applicableNot applicable
7784-09-0Phosphoric acid, trisilver(1+) saltNot applicableNot applicable
7789-45-9Copper bromide (CuBr2)Not applicableNot applicable
7790-80-9Cadmium iodide (CdI2)Not applicableNot applicable
7790-86-5Cerium chloride (CeCl3)Not applicableNot applicable
7790-98-9Perchloric acid, ammonium saltNot applicableNot applicable
7803-58-9SulfamideNot applicableNot applicable
7803-63-6Sulfuric acid, monoammonium saltNot applicableNot applicable
8023-64-1Balsams, Peru, whiteNot applicableFragrance/ Flavourant
8038-93-5Sodium aluminum chlorhydroxy lactateNot applicableNot applicable
9008-34-8Resin acids and Rosin acids, manganese saltsNot applicableNot applicable
10024-42-7Aluminum sodium sulfateNot applicableNot applicable
10024-93-8Neodymium chloride (NdCl3)Not applicableNot applicable
10025-67-9Sulfur chloride (S2Cl2)Not applicableNot applicable
10025-74-8Dysprosium chloride (DyCl3)Not applicableNot applicable
10028-17-8TritiumNot applicableNot applicable
10042-88-3Terbium chloride (TbCl3)Not applicableNot applicable
10045-89-3Sulfuric acid, ammonium iron(2+) salt (2:2:1)Not applicableNot applicable
10049-07-7Rhodium chloride (RhCl3)Not applicableNot applicable
10049-23-7Telluric acid (H2TeO3)Not applicableNot applicable
10099-59-9Nitric acid, lanthanum(3+) saltNot applicableNot applicable
10102-05-3Nitric acid, palladium(2+) saltNot applicableNot applicable
10108-73-3Nitric acid, cerium(3+) saltNot applicableNot applicable
10138-04-2Sulfuric acid, ammonium iron(3+) salt (2:1:1)Not applicableNot applicable
10138-41-7Erbium chloride (ErCl3)Not applicableNot applicable
10138-52-0Gadolinium chloride (GdCl3)Not applicableNot applicable
10168-81-7Nitric acid, gadolinium(3+) saltNot applicableNot applicable
10361-65-6Phosphoric acid, triammonium saltNot applicableFertilizer
10361-79-2Praseodymium chloride (PrCl3)Not applicableNot applicable
10361-82-7Samarium chloride (SmCl3)Not applicableNot applicable
10361-92-9Yttrium chloride (YCl3)Not applicableNot applicable
10361-93-0Nitric acid, yttrium(3+) saltNot applicableNot applicable
10402-16-19-Octadecenoic acid (Z)-, copper saltNot applicableNot applicable
10402-33-2Benzeneacetic acid, 2-methoxy-4-(2-propenyl)phenyl esterNot applicableFormulant
10484-56-7Naphthalene, 2-butoxy-Not applicableFragrance/ Flavourant
10579-93-8Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, [1S-(1R,4E,9S)]-Not applicableNot applicable
10580-02-6Titanate(2-), bis[ethanedioato(2-)-O,O ']oxo-, diammonium, (SP-5-21)-Not applicableNot applicable
11028-42-5CedreneNot applicableFormulant
12003-63-3Aluminate (AlO21-), potassiumNot applicableNot applicable
12004-40-9Aluminate (AlO33-), strontium (2:3)Not applicableNot applicable
12013-15-9Copper hydroxide sulfate (Cu3(OH)4(SO4))Not applicableNot applicable
12014-14-1Cadmium titanium oxide (CdTiO3)Not applicableNot applicable
12027-06-4Ammonium iodide ((NH4)I)Not applicableNot applicable
12027-67-7Molybdate (Mo7O246-), hexaammoniumNot applicableNot applicable
12030-97-6Titanate (TiO32-), dipotassiumNot applicableNot applicable
12034-34-3Titanate (TiO32-), disodiumNot applicableNot applicable
12049-50-2Titanate (TiO32-), calcium (1:1)Not applicableNot applicable
12057-24-8Lithium oxide (Li2O)Not applicableNot applicable
12061-16-4Erbium oxide (Er2O3)Not applicableNot applicable
12075-68-2Aluminum, trichlorotriethyldi-Not applicableNot applicable
12124-99-1Ammonium sulfide ((NH4)(SH))Not applicableFragrance/ Flavourant
12135-77-2Ammonium sulfide ((NH4)2(S5))Not applicableNot applicable
12138-09-9Tungsten sulfide (WS2)Not applicableNot applicable
12192-57-3Gold, [1-(thio-.kappa.S)-D-glucopyranosato-.kappa.O2Not applicableNot applicable
12196-21-3Hemimorphite (Zn4(OH)2O(SiO3)2.H2O)Not applicableNot applicable
12227-77-9Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, chloride, aluminum saltNot applicableNot applicable
12254-24-9Aluminate (Al12O192-), strontium (1:1)Not applicableNot applicable
12307-90-3Rhodium, chloro[(1,2,5,6-η)-1,3,5,7-cyclooctatetraene](pyridine)-Not applicableNot applicable
12542-85-7Aluminum, trichlorotrimethyldi-Not applicableNot applicable
12593-60-1Ammonium phosphate sulfate ((NH4)2H3(PO4)(SO4))Not applicableFertilizer
12794-95-5Silicic acid, ammonium saltNot applicableNot applicable
13005-35-1D-Gluconic acid, copper saltNot applicableNot applicable
13011-54-6Phosphoric acid, monoammonium monosodium saltNot applicableNot applicable
13019-04-0Cyclohexanone, 2,4-bis(1,1-dimethylethyl)-Not applicableFragrance/ Flavourant
13106-76-8Molybdate (MoO42-), diammonium, (T-4)-Not applicableFertilizer
13393-93-61-Phenanthrenemethanol, tetradecahydro-1,4a-dimethyl-7-(1-methylethyl)-Not applicableFragrance/ Flavourant
13444-93-4Osmium chloride (OsCl3)Not applicableNot applicable
13446-48-5Nitrous acid, ammonium saltNot applicableNot applicable
13453-07-1Gold chloride (AuCl3)Not applicableNot applicable
13453-87-7Sulfurous acid, dilithium saltNot applicableNot applicable
13454-72-3Metaphosphoric acid (HPO3), cerium(3+) saltNot applicableNot applicable
13465-98-0Sulfurous acid, disilver(1+) saltNot applicableNot applicable
13573-16-5Chromate(1-), diamminetetrakis(thiocyanato-N)-, ammonium, (OC-6-11)-Not applicableNot applicable
13596-12-8Aluminum fluoride oxide (AlFO)Not applicableNot applicable
13598-65-7Rhenate (ReO41-), ammonium, (T-4)-Not applicableNot applicable
13693-11-3Sulfuric acid, titanium(4+) salt (2:1)Not applicableNot applicable
13709-38-1Lanthanum fluoride (LaF3)Not applicableNot applicable
13709-49-4Yttrium fluoride (YF3)Not applicableNot applicable
13786-79-313-Oxabicyclo[10.1.0]trideca-4,8-diene, 1,5,9-trimethyl-Not applicableFragrance/ Flavourant
13820-53-6Palladate(2-), tetrachloro-, disodium, (SP-4-1)-Not applicableNot applicable
13821-15-3Aluminate(1-), tetrafluoro-, sodium, (T-4)-Not applicableNot applicable
13823-29-5Nitric acid, thorium(4+) saltNot applicableNot applicable
14049-51-5Aluminum, hydroxybis(octanoato-O)-Not applicableNot applicable
14220-17-8Nickelate(2-), tetrakis(cyano-C)-, dipotassium, (SP-4-1)-Not applicableNot applicable
14263-73-1Cuprate(3-), tetrakis(cyano-C)-, tripotassium, (T-4)-Not applicableNot applicable
14284-93-6Ruthenium, tris(2,4-pentanedionato-O,O ')-, (OC-6-11)-Not applicableNot applicable
14307-35-8Chromic acid (H2CrO4), dilithium saltNot applicableNot applicable
14475-17-3Carbonic acid, praseodymium saltNot applicableNot applicable
14816-18-33,5-Dioxa-6-aza-4-phosphaoct-6-ene-8-nitrile, 4-ethoxy-7-phenyl-, 4-sulfideYes (Human Health)Not applicable
15007-61-1Aluminum potassium sulfateNot applicableNot applicable
15114-15-59,10-Anthracenedione, 4,8-diamino-2-(4-ethoxyphenyl)-1,5-dihydroxy-Not applicableNot applicable
15281-91-1Cuprate(3-), tetrakis(cyano-C)-, trisodium, (T-4)-Not applicableNot applicable
15336-18-2Rhodate(3-), hexachloro-, triammonium, (OC-6-11)-Not applicableNot applicable
15467-06-89-Octadecenoic acid, 12-hydroxy-, monolithium salt, [R-(Z)]-Not applicableNot applicable
15680-42-9Copper, [1-[[(2-hydroxyphenyl)imino]methyl]-2-naphthalenolato(2-)-N,O,O ']-Not applicableNot applicable
15710-63-1Aluminum ammonium sulfateNot applicableNot applicable
15752-05-3Iridate(3-), hexachloro-, triammonium, (OC-6-11)-Not applicableNot applicable
16774-21-3Cerate(2-), hexakis(nitrato-O)-, diammonium, (OC-6-11)-Not applicableNot applicable
16871-54-8Platinate(2-), hexachloro-, (OC-6-11)-Not applicableNot applicable
16903-35-8Aurate(1-), tetrachloro-, hydrogen, (SP-4-1)-Not applicableNot applicable
16919-19-0Silicate(2-), hexafluoro-, diammoniumNot applicableNot applicable
16919-31-6Zirconate(2-), hexafluoro-, diammonium, (OC-6-11)-Not applicableNot applicable
16919-58-7Platinate(2-), hexachloro-, diammonium, (OC-6-11)-Not applicableNot applicable
16921-30-5Platinate(2-), hexachloro-, dipotassium, (OC-6-11)-Not applicableNot applicable
16923-58-3Platinate(2-), hexachloro-, disodium, (OC-6-11)-Not applicableNot applicable
16940-92-4Iridate(2-), hexachloro-, diammonium, (OC-6-11)-Not applicableNot applicable
16941-12-1Platinate(2-), hexachloro-, dihydrogen, (OC-6-11)-Not applicableNot applicable
17202-41-41-Nonanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-nonadecafluoro-, ammonium saltNot applicableNot applicable
17439-11-1Titanate(2-), hexafluoro-, dihydrogen, (OC-6-11)-Not applicableNot applicable
17527-29-62-Propenoic acid, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl esterNot applicableNot applicable
17831-71-92-Propenoic acid, oxybis(2,1-ethanediyloxy-2,1-ethanediyl) esterNot applicableNot applicable
17836-88-3Aluminate(1-), diethyldihydro-, sodium, (T-4)-Not applicableNot applicable
18263-25-7Hexadecanoic acid, 2-bromo-Not applicableNot applicable
18400-34-5Bismuth carbonateNot applicableNot applicable
18908-70-8Benzene, 1-ethyl-2-(1-phenylethyl)-Not applicableNot applicable
18908-71-9Benzene, 1-ethyl-3-(1-phenylethyl)-Not applicableNot applicable
19014-53-09,10-Anthracenedione, 1-amino-2-[4-[(hexahydro-2-oxo-1H-azepin-1-yl)methyl]phenoxy]-4-hydroxy-Yes (Ecological)Not applicable
19125-99-61H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(butylamino)-Not applicableNot applicable
19398-61-9Benzene, 1,4-dichloro-2-methyl-Not applicableNot applicable
19941-28-71-Phenanthrenecarboxylic acid, tetradecahydro-1,4a-dimethyl-7-(1-methylethyl)-, methyl ester, [1R-(1α,4aß,4bα-,7ß,8aß,10aα)]-Not applicableNot applicable
21064-19-71,5,9-Cyclododecatriene, 1,5,9-trimethyl-Not applicableNot applicable
21656-02-0Rhodium hydroxide (Rh(OH)3)Not applicableNot applicable
22722-98-1Aluminate(1-), dihydrobis(2-methoxyethanolato-O,O ')-, sodiumNot applicableNot applicable
23149-52-2Thiosulfuric acid (H2S2O3), disilver(1+) saltNot applicableNot applicable
24304-00-5Aluminum nitride (AlN)Not applicableNot applicable
24447-78-72-Propenoic acid, (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl)
ester
Not applicableNot applicable
24484-01-3Copper, chloro[tris(2-chloroethyl) phosphite-P]-Not applicableNot applicable
24593-34-8Hexanoic acid, 2-ethyl-, cerium saltNot applicableNot applicable
24772-51-8Aluminum, bis(2-butanolato)(ethyl 3-oxobutanoato-O1 ',O3)-, (T-4)-Not applicableNot applicable
25155-18-4Benzenemethanaminium, N,N-dimethyl-N-[2-[2-[methyl-4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl]-, chlorideNot applicableNot applicable
25339-17-7IsodecanolNot applicableFragrance/ Flavourant
25567-55-9Phenol, tetrachloro-, sodium saltNot applicableNot applicable
25614-03-3Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'α)-Not applicablePharmaceutical
26401-27-4Phosphorous acid, isooctyl diphenyl esterNot applicableNot applicable
26545-58-4Naphthalenesulfonic acid, methylenebis-, disodium saltNot applicableNot applicable
26603-40-71,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(3-isocyanatomethylphenyl)-Not applicableNot applicable
26628-22-8Sodium azide (Na(N3))Not applicableNot applicable
26747-90-01,3-Diazetidine-2,4-dione, 1,3-bis(3-isocyanatomethylphenyl)-Not applicableNot applicable
27080-90-6Disulfide, bis(dimethylphenyl)Not applicableNot applicable
27157-94-4Phosphorodithioic acid, O,O-bis(methylphenyl) esterNot applicableNot applicable
27441-86-7Imidodisulfuric acid, ammonium saltNot applicableNot applicable
28984-89-61,1 '-Biphenyl, phenoxy-Not applicableNot applicable
29935-35-1Arsenate(1-), hexafluoro-, lithiumNot applicableNot applicable
31113-23-2Aurate(1-), tetrachloro-, ammonium, (SP-4-1)-Not applicableNot applicable
31288-44-59,10-Anthracenedione, 1,5-diamino-4,8-dihydroxy(4-methoxyphenyl)-Not applicableNot applicable
31529-83-69,10-Anthracenedione, 1,5-diamino-4,8-dihydroxy(4-hydroxyphenyl)-Not applicableNot applicable
31884-77-2Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, hydrochloride, hydrate (1:2:1)Not applicableNot applicable
32222-06-39,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1α,3β,5Z,7E)-Not applicablePharmaceutical
32510-27-32(3H)-Benzothiazolethione, copper saltNot applicableNot applicable
33703-04-7Acetic acid, 2,2 ',2 ' '-[(1,1,3-tributyl-1-distannathianyl-3-ylidene)tris(thio)]tris-, triisooctyl esterNot applicableNot applicable
33704-59-51H-Indene, 2,3,4,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-Not applicableNot applicable
33704-60-81H-Indene, octahydro-1,1,2,3,3-pentamethyl-Not applicableFragrance/ Flavourant
34455-03-31-Hexanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-N-(2-hydroxyethyl)-Not applicableNot applicable
35164-39-7Propanoic acid, 2-methyl-, ester with 2,2,4-trimethyl-1,3-pentanediol monobenzoateNot applicableNot applicable
35171-52-9Arsenic triiodideNot applicableNot applicable
38303-23-0Cyclododecoxazole, 4,5,6,7,8,9,10,11,12,13-decahydro-Not applicableFragrance/ Flavourant
38462-23-6Pyridine, 4-(4,8-dimethyl-3,7-nonadienyl)-Not applicableFormulant
38970-76-2Benzoic acid, 2-hydroxy-, dilithium saltNot applicableNot applicable
40785-62-4Cyclododeca[c]furan, 1,3,3a,4,5,6,7,8,9,10,11,13a-dodecahydro-Not applicableFragrance/ Flavourant
41284-31-51,4-Benzenedicarboxylic acid, 2-[[4-(2,2-dicyanoethenyl)-3-methylphenyl]ethylamino]ethyl methyl esterYes (Ecological)Not applicable
42757-85-71H-Benz[f]indene-1,3(2H)-dione, 2-(3-hydroxy-2-quinolinyl)-Not applicableNot applicable
47107-74-4Copper, iodo(triphenylphosphine)-Not applicableNot applicable
47742-71-2Xanthylium, 3,6-bis(diethylamino)-9-[2-(methoxycarbonyl)phenyl]-Yes (Ecological)Not applicable
50288-23-8Arsenic triiodideNot applicableNot applicable
50471-44-82,4-Oxazolidinedione, 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-Yes (Human Health)Historical Pesticide Active
50542-90-02H-1-Benzopyran-2-one, 7-[(3,7-dimethyl-2,6-octadienyl)oxy]-4-methyl-Not applicableFormulant
52236-80-3Acetic acid, [4-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthracenyl)oxy]phenoxy]-, ethyl esterYes (Ecological)Not applicable
52475-89-53-Cyclohexene-1-carboxaldehyde, 3-(4-methyl-3-pentenyl)-Not applicableFormulant
52591-27-22-Propenoic acid, 3,3,4,4,5,5,6,6,6-nonafluorohexyl esterNot applicableNot applicable
53004-93-6Butanoic acid, 2-methyl-, 5-methyl-2-(1-methylethyl)cyclohexyl esterNot applicableFragrance/ Flavourant
53422-16-5Octadecanoic acid, 12-hydroxy-, methyl ester, lithium saltNot applicableNot applicable
54464-54-9Ethanone, 1-[1,6-dimethyl-3-(4-methyl-3-pentenyl)-3-cyclohexen-1-yl]-Not applicableNot applicable
55200-89-0Copper hydroxide sulfateNot applicableNot applicable
56208-99-2Aluminum, bis(2-ethylhexanoato-O)(2-propanolato)-Not applicableNot applicable
56211-60-0Potassium titanium fluorideNot applicableNot applicable
57499-57-7Ethanone, 1-[1,6-dimethyl-4-(4-methyl-3-pentenyl)-3-cyclohexen-1-yl]-Not applicableNot applicable
58102-02-63-Butenal, 2-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-Not applicableFragrance/ Flavourant
58394-64-2Hexanedioic acid, 2-ethylhexyl phenylmethyl esterNot applicableNot applicable
58478-76-5Octadecanoic acid, 12-hydroxy-, calcium lithium saltNot applicableNot applicable
60270-55-51-Heptanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-, potassium saltNot applicableNot applicable
60304-36-1Aluminum potassium fluorideNot applicableNot applicable
60364-28-5Pentanoic acid, 2-propyl-, bismuth saltNot applicableNot applicable
61617-09-29H-Dibenzo[b,d]pyran-9-one, 3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl -, (6aR,10aR)-Not applicableNot applicable
61788-56-5Naphthenic acids, lithium saltsNot applicableNot applicable
61788-80-5Resin acids and Rosin acids, iron saltsNot applicableNot applicable
61788-83-8Oils, herring, sulfated, sodium saltsNot applicableNot applicable
61789-75-1Quaternary ammonium compounds, benzyldimethyltallow alkyl, chloridesNot applicableNot applicable
61790-11-2Fatty acids, tall-oil, zinc saltsYes (Ecological)Formulant
61790-20-3Naphthenic acids, rare earth saltsNot applicableNot applicable
61790-54-3Naphthenic acids, compds. with N-tallow alkyltrimethylenediaminesYes (Ecological)Not applicable
62563-80-8Vetiverol, acetateNot applicableFragrance/ Flavourant
62625-30-3Phenol, 4,4 '-(3H-2,1-benzoxathiol-3-ylidene)bis[2-bromo-6-methyl-, S,S-dioxide, monosodium saltNot applicableNot applicable
62638-04-4Cyclohexanebutanoic acid, silver(1+) saltNot applicableNot applicable
63148-76-5Benzoxazolium, 3-ethyl-5-phenyl-2-[2-[[3-(3-sulfopropyl)-2(3H)-benzoxazolylidene]methyl]-1-butenyl]-, hydroxide, inner saltYes (Ecological)Not applicable
63568-35-4Naphthalenedisulfonic acid, diisononyl-, compd. with 1,1 '-iminobis[2-propanol] (1:2)Yes (Ecological)Not applicable
64129-94-8Pentanoic acid, 5-methyl-2-(1-methylethyl)cyclohexyl ester, [1R-(1α,2β,5α)]-Not applicableFragrance/ Flavourant
64754-89-8Naphthenic acids (petroleum), crudeNot applicableNot applicable
64755-02-8Fatty acids, tallow, lithium saltsNot applicableNot applicable
65816-20-8Benzoic acid, 4-[[(ethylphenylamino)methylene]amino]-, ethyl esterNot applicableNot applicable
66071-82-7Fatty acids, tallow, hydrogenated, lithium saltsNot applicableNot applicable
67567-23-1Butanoic acid, 3,3-bis[(1,1-dimethylpropyl)dioxy]-, ethyl esterNot applicableNot applicable
67584-53-6Glycine, N-ethyl-N-[(tridecafluorohexyl)sulfonyl]-, potassium saltNot applicableFormulant
67584-58-11-Propanaminium, N,N,N-trimethyl-3-[[(pentadecafluoroheptyl)sulfonyl]amino]-, iodideNot applicableNot applicable
67584-62-7Glycine, N-ethyl-N-[(pentadecafluoroheptyl)sulfonyl]-, potassium saltNot applicableFormulant
67634-12-2Benzoic acid, 2-[[[4-(4-hydroxy-4-methylpentyl)-3-cyclohexenyl]methylene]amino]-, methyl esterNot applicableFormulant
67801-30-34-Penten-3-one, 5-(2,4,6-trimethyl-3-cyclohexen-1-yl)-Not applicableFragrance/ Flavourant
67801-31-43-Buten-2-one, 3-methyl-4-(3,5,6-trimethyl-3-cyclohexen-1-yl)-Not applicableFragrance/ Flavourant
67801-32-54-Penten-3-one, 5-(3,5,6-trimethyl-3-cyclohexen-1-yl)-Not applicableFragrance/ Flavourant
67801-36-91H-Indole-1-heptanol, η-1H-indol-1-yl-α,α,ε-trimethylNot applicableFragrance/ Flavourant
67801-37-01H-Indole, 1,1 '-(2-phenylethylidene)bis-Not applicableFragrance/ Flavourant
67801-47-2Benzoic acid, 2-[(3,7-dimethyl-2,6-octadienylidene)amino]-, methyl esterNot applicableFragrance/ Flavourant
67845-42-5Benzoic acid, 2-[(3,7-dimethyl-6-octenylidene)amino]-, methyl esterNot applicableFragrance/ Flavourant
67893-02-11-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a-dimethyl-7-(1-methylethyl)-, methyl esterNot applicableNot applicable
67905-40-2Oxiranecarboxylic acid, 3-methyl-3-[2-(2,6,6-trimethyl-2-cyclohexen-1-yl)ethenyl]-, methyl esterNot applicableFragrance/ Flavourant
67924-13-4Benzoic acid, 2-[[2-(phenylmethylene)octylidene]amino]-, methyl esterNot applicableFragrance/ Flavourant
67939-98-41-Heptanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-N-[2-(phosphonooxy)ethyl]-, diammonium saltNot applicableNot applicable
67940-02-71-Heptanesulfonamide, N-[3-(dimethylamino)propyl]-1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-, monohydrochlorideNot applicableNot applicable
68039-12-31H-Imidazolium, 1-ethyl-4,5-dihydro-3-(2-hydroxyethyl)-2-(8-heptadecenyl)-, ethyl sulfateNot applicableNot applicable
68083-40-9Methanone, [2-hydroxy-4-[2-hydroxy-3-(octyloxy)propoxy]phenyl]phenyl-Yes (Ecological)Not applicable
68092-49-9Methanone, [4-[3-(decyloxy)-2-hydroxypropoxy]-2-hydroxyphenyl]phenyl-Not applicableNot applicable
68131-32-8Sulfite liquors and Cooking liquors, spent, fermentedNot applicableFertilizer
68139-87-7Fatty acids, tall-oil, compds. with diethylenetriamine-naphthenic acid reaction productsNot applicableNot applicable
68155-64-61-Propanone, 1-[6-methyl-3-(4-methyl-3-pentenyl)-3-cyclohexen-1-yl]-Not applicableNot applicable
68155-65-71-Propanone, 1-[6-methyl-4-(4-methyl-3-pentenyl)-3-cyclohexen-1-yl]-Not applicableNot applicable
68186-32-31,2,4-Benzenetricarboxylic acid, isooctyl esterNot applicableNot applicable
68186-99-2C.I. Pigment Red 231Not applicableNot applicable
68187-06-4Naphthalenesulfonic acid, di-C5-6-alkyl derivs., compds. with butylamineNot applicableNot applicable
68187-41-7Phosphorodithioic acid, O,O-di-C1-14-alkyl estersNot applicableNot applicable
68187-59-7Coal, anthracite, calcinedNot applicableNot applicable
68201-19-4Barium, acetate tallow fatty acids complexesYes (Ecological)Not applicable
68228-09-1Benzoic acid, 2-[[[2,4(or 3,5)-dimethyl-3-cyclohexen-1-yl]methyl]amino]-, ethyl esterYes (Ecological)Fragrance/ Flavourant
68259-07-41-Heptanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-, ammonium saltNot applicableNot applicable
68259-14-31-Heptanesulfonamide, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-N-methyl-Not applicableNot applicable
68259-15-41-Hexanesulfonamide, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-N-methyl-Not applicableNot applicable
68298-13-51-Pentanesulfonamide, 1,1,2,2,3,3,4,4,5,5,5-undecafluoro-N-methyl-Not applicableNot applicable
68307-87-9Calcium, acetate hydrogenated tallow fatty acids complexesNot applicableNot applicable
68308-19-0Fatty acids, C6-19-branched, copper(2+) saltsNot applicableNot applicable
68309-34-2Imidazolium compounds, 1-benzyl-4,5-dihydro-1-(hydroxyethyl)-2-nortall-oil alkyl, chloridesNot applicableNot applicable
68333-32-4Phenol, mixed di-Me and mono-Me derivs., isobutenylated, distn. residuesNot applicableNot applicable
68334-11-2Fatty acids, tall oil, compds. with 2-[(2-hydroxyphenyl)methylene]hydrazinecarboximidamideYes (Ecological)Not applicable
68400-01-1Formic acid, compd. with 2-[2-[[4-[3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]phenyl]sulfonyl]ethoxy]-N,N-dimethyl-1-propanamine (1:1)Not applicableNot applicable
68412-02-22,5-Furandione, dihydro-, mono-C11-13-alkenyl derivs.Not applicableNot applicable
68412-83-9Sulfuric acid, mono-C8-30-alkyl esters, compds. with triethanolamineNot applicableNot applicable
68442-12-69-Octadecenoic acid (Z)-, 2-mercaptoethyl ester, reaction products with dichlorodimethylstannane, sodium sulfide(Na2S) and trichloromethylstannaneNot applicableNot applicable
68478-78-49-Octadecenoic acid (Z)-, reaction products with 2-amino-2-methyl-1-propanolNot applicableNot applicable
68478-92-2Platinum, 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane complexesNot applicableNot applicable
68514-63-6Naphthenic acids, cerium(4+) saltsNot applicableNot applicable
68515-67-3Copper, 2-ethylhexanoate naphthenate 3,5,5-trimethylhexanoate complexesNot applicableNot applicable
68515-89-9Barium, carbonate nonylphenol complexesNot applicableNot applicable
68515-93-5Phenol, nonyl derivs., sulfidesNot applicableNot applicable
68527-78-6Benzoic acid, 2-[[2-(phenylmethylene)heptylidene]amino]-, methyl esterNot applicableFragrance/ Flavourant
68527-79-77-Octen-2-ol, 8-(1H-indol-1-yl)-2,6-dimethylNot applicableFragrance/ Flavourant
68551-38-2Balsams, copaiba, sulfurized, silver saltsNot applicableNot applicable
68551-39-3Balsams, Douglas-fir, mixed with turpentine oil, titanium saltsNot applicableNot applicable
68555-62-42-Butenal, 2-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-Not applicableFragrance/ Flavourant
68555-72-61-Pentanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,5-undecafluoro-N-(2-hydroxyethyl)-Not applicableNot applicable
68555-73-71-Heptanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-N-(2-hydroxyethyl)-Not applicableNot applicable
68555-75-91-Hexanesulfonamide, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-N-(2-hydroxyethyl)-N-methyl-Not applicableNot applicable
68555-76-01-Heptanesulfonamide, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-N-(2-hydroxyethyl)-N-methyl-Not applicableNot applicable
68555-81-71-Propanaminium, N,N,N-trimethyl-3-[[(pentadecafluoroheptyl)sulfonyl]amino]-, chlorideNot applicableNot applicable
68585-32-0Platinate(2-), hexachloro-, (OC-6-11)-, dihydrogen, reaction products with 2,4,6,8-tetraethenyl-2,4,6,8-tetramethylcyclotetrasiloxaneNot applicableNot applicable
68603-64-5Amines, N-(hydrogenated tallow alkyl)trimethylenedi-Yes (Ecological)Not applicable
68608-33-3Terpenes and Terpenoids, cedarwood-oil, hydroxy, acetatesNot applicableNot applicable
68609-03-0Copper, C6-19-branched carboxylate naphthenate complexesNot applicableNot applicable
68610-24-2C.I. Pigment Yellow 157healthNot applicable
68611-23-43-Pentanone, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, reaction products with 2-propyn-1-olNot applicableFormulant
68647-36-9Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, tungstatesilicateNot applicableNot applicable
68647-67-6Sesquiterpenes and Sesquiterpenoids, guaiac wood-oilNot applicableFormulant
68648-44-2Pyrethrins and Pyrethroids, manufg.-residuesYes (Ecological)Formulant
68683-18-1Neodecanoic acid, silver(1+) saltNot applicableNot applicable
68738-99-8Benzoic acid, 2-[[[2,4(or 3,5)-dimethyl-3-cyclohexen-1-yl]methylene]amino]-, methyl esterNot applicableFormulant
68784-83-8Yttrium oxide sulfide (Y2O2S), europium-dopedNot applicableNot applicable
68845-33-0Cyclohexane, 1-ethenyl-1-methyl-2-(1-methylethenyl)-4-(1-methylethyl)-, didehydro deriv.Not applicableFragrance/ Flavourant
68859-25-6C.I. Pigment Yellow 37Not applicableNot applicable
68901-22-4Cyclohexanone, 4-[(3,3-dimethylbicyclo[2.2.1]hept-2-yl)methyl]-2-methyl-Not applicableFormulant
68908-88-3Benzene, ethyl-, benzylatedNot applicableNot applicable
68909-13-7Bastnaesite, calcined conc.Not applicableNot applicable
68916-14-3Oils, amyris, acetylatedNot applicableFragrance/ Flavourant
68916-31-4Balsams, Douglas-fir, sulfurized, ruthenium saltsNot applicableNot applicable
68916-32-5Balsams, mixed copaiba and Douglas-fir, sulfurized, silver saltsNot applicableNot applicable
68918-07-0Sulfonic acids, petrolatum, sodium saltsNot applicableNot applicable
68920-10-5Fats, animal, mixed with vegetable oils, deodorizer distillatesNot applicableNot applicable
68922-09-8Cyclohexanol, 2-methoxy-4-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-Not applicableFragrance/ Flavourant
68928-29-01-Octadecanaminium, N,N-diethyl-N-methyl-, (OC-6-11)-hexakis(cyano-C)ferrate(4-) (4:1)Not applicableNot applicable
68938-42-1Paraffin waxes and Hydrocarbon waxes, chloro, reaction products with naphthaleneNot applicableNot applicable
68952-33-0Tar acids, cresylic, C8-rich, phosphatesNot applicableNot applicable
68952-90-91-Propanaminium, N,N-bis(2-aminoethyl)-2-hydroxy-N-methyl-, N,N '-ditallow acyl derivs., Me sulfates (salts)Not applicableNot applicable
68954-59-69-Octadecenoic acid (Z)-, reaction products with 2-[(2-aminoethyl)amino]ethanol, compds. with di-Et sulfateNot applicableNot applicable
68955-54-4Amines, C16-22-tert-alkylNot applicableNot applicable
68956-12-7Fatty acids, C18-unsatd., dimers, distn. lightsNot applicableNot applicable
68957-60-81-Pentanesulfonamide, N-[3-(dimethylamino)propyl]-1,1,2,2,3,3,4,4,5,5,5-undecafluoro-, monohydrochlorideNot applicableNot applicable
68957-61-91-Hexanesulfonamide, N-[3-(dimethylamino)propyl]-1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, monohydrochlorideNot applicableNot applicable
68957-62-01-Heptanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-Not applicableNot applicable
68990-00-1Resin acids and Rosin acids, decarboxylated, potassium saltsNot applicableNot applicable
68990-27-2Balsams, copaiba, sulfurized, mixed with turpentine, gold saltsNot applicableNot applicable
68990-92-1Tallow, reaction products with 2-[(2-aminoethyl)amino]ethanol, compds. with di-Et sulfateNot applicableNot applicable
69011-12-71,2-Benzenedicarboxylic acid, 3,4,5,6-tetrachloro-, butyl esterNot applicableNot applicable
69012-57-3Flue dust, cadmium-refiningNot applicableNot applicable
69012-60-8Flue dust, lead-tin alloy-manufg.Not applicableNot applicable
69012-63-1Flue dust, zinc-refiningNot applicableNot applicable
69012-86-8Ashes (residues), zinc-refiningNot applicableNot applicable
69029-45-4Lead, dross, antimony-richNot applicableNot applicable
69029-51-2Lead, antimonial, drossNot applicableNot applicable
69029-60-3Zinc, desilverizing skimsNot applicableNot applicable
69029-61-4Bismuth, refinery lead chloride residuesNot applicableNot applicable
69029-63-6Calcines, cadmium residueNot applicableNot applicable
69029-74-9Calcines, lead ore conc.Not applicableNot applicable
69029-79-4Residues, lead smeltingNot applicableNot applicable
69029-83-0Residues, zinc smeltingNot applicableNot applicable
69029-91-0Slimes and Sludges, cadmium sump tankNot applicableNot applicable
70024-67-8Benzenesulfonic acid, C16-24-alkyl derivs.Not applicableNot applicable
70225-15-91-Heptanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-, compd. with 2,2 '-iminobis[ethanol] (1:1)Not applicableNot applicable
70225-16-01-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, compd. with 2,2 '-iminobis[ethanol] (1:1)Not applicableNot applicable
70892-62-51-Naphthalenepropanol, α-ethenyldecahydro-2-hydroxy-α,2,5,5,8a-pentamethyl-, [1R-[1α(R),2β,4aβ,8aα]]-, oxidizedNot applicableFragrance/ Flavourant
70914-18-0Tallow, hydrogenated, reaction products with 2-[(2-aminoethyl)amino]ethanol, compds. with di-Et sulfatesNot applicableNot applicable
71205-27-19,10-Anthracenedione, 1,8-diamino-4,5-dihydroxy-, brominatedNot applicableNot applicable
71487-01-9Quaternary ammonium compounds, dicoco alkyldimethyl, nitritesYes (Ecological)Not applicable
71827-03-7Avermectin A1a, 5-O-demethyl-22,23-dihydro-Not applicableNot applicable
71889-01-5Silane, chlorotrimethyl-, hydrolysis products with silicaNot applicableFormulant
72230-85-4Terpenes and Terpenoids, copaiba-oil, hydroxy, acetatesNot applicableFragrance/ Flavourant
72403-67-93-Cyclohexene-1-methanol, 3(or 4)-(4-methyl-3-pentenyl)-, acetateNot applicableFragrance/ Flavourant
72749-59-8Quaternary ammonium compounds, tri-C6-12-alkylmethyl, chloridesNot applicableNot applicable
72927-96-92-Anthracenesulfonic acid, 1-amino-9,10-dihydro-9,10-dioxo-4-[(2,4,6-trimethylphenyl)amino]-, monolithium saltNot applicableNot applicable
73018-55-0Platinum, dicarbonyldichloro-, reaction products with 2,4,6-triethenyl-2,4,6-trimethylcyclotrisiloxaneNot applicableNot applicable
73049-75-9Quaternary ammonium compounds, benzyldi-C12-18-alkylmethyl, chloridesNot applicableNot applicable
73240-13-8Benzoic acid, 2-hydroxy-, 1-methyl-1,3-propanediyl esterNot applicableNot applicable
73309-46-3Ethanaminium, N-[4-[[4-(diethylamino)phenyl][4-[(4-ethoxyphenyl)amino]-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, chlorideNot applicableNot applicable
73570-52-2Phenoxazin-5-ium, 3,7-bis(diethylamino)-, nitrateNot applicableFormulant
75701-31-4Xanthylium, 9-(2,5-dicarboxyphenyl)-3,6-bis(diethylamino)-, hydroxide, inner saltNot applicableNot applicable
79665-42-2Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(diethylamino)-, copper(1+) (OC-6-11)-hexakis(cyano-C)ferrate(4-) (2:2:1)Not applicableNot applicable
79864-11-2Benzenamine, N,N '-methanetetraylbis[4-[(4-isocyanatophenyl)methyl]-Not applicableNot applicable
80301-64-01H-Benzotriazole-1-methanamine, N,N-bis(2-ethylhexyl)-Not applicableNot applicable
82537-67-51,3,8-Triazaspiro[4.5]decane-2,4-dione, 8-acetyl-3-dodecyl-7,7,9,9-tetramethyl-Not applicableNot applicable
83950-19-0Benzenamine, 4-[(2-chlorophenyl)[4-(ethylimino)-3-methyl-2,5-cyclohexadien-1-ylidene]methyl]-N-ethyl-2-methyl-, sulfate (2:1)Not applicableNot applicable
83968-92-7Ethanaminium, N-[4-[(2-chlorophenyl)(1-methyl-2-phenyl-1H-indol-3-yl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, acetateNot applicableNot applicable
84434-47-9Methanaminium, N-[4-[[4-(dimethylamino)phenyl][4-(methylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, acetateNot applicableNot applicable
84776-83-0Resin acids and Rosin acids, esters with trimethylolpropaneNot applicableNot applicable
85005-73-8Phenoxazin-5-ium, 3-(ethylamino)-2-methyl-7-[(2-methylphenyl)amino]-, chlorideNot applicableNot applicable
85187-74-2Benzenesulfonic acid, 2,2 '-(1,2-ethenediyl)bis[5-[[4-(methylamino)-6-(phenylamino)-1,3,5-triazin-2-yl]amino]-, sodium saltNot applicableNot applicable
85338-07-4Aluminum, chloro hydroxy sulfo-1,2-benzenedicarboxylate complexesNot applicableNot applicable
85585-93-9Carbonic acid, aluminum magnesium salt, basicNot applicableNot applicable
85586-48-7Urea, N,N ' '-(methylenedi-4,1-phenylene)bis[N '-[3-(triethoxysilyl)propyl]-Not applicableNot applicable
85736-59-0Naphthenic acids, bismuth saltsNot applicableNot applicable
87396-22-3Phosphonic acid, [[(phosphonomethyl)imino]bis[6,1-hexanediylnitrilobis(methylene)]]tetrakis-, reaction products with ammonia-diethylene glycol reaction product morpholine derivs. residuesNot applicableNot applicable
90066-13-0Xanthylium, 9-(2,4-dicarboxyphenyl)-3,6-bis(diethylamino)-, hydroxide, inner saltNot applicableNot applicable
90623-14-6Amides, from C18-24 fatty acids, N,N-dimethyl-1,3-propanediamine and hydrogenated tallow fatty acids, compds. with di-Me sulfateNot applicableNot applicable
90989-74-5Blood, mealNot applicableFertilizer
91053-53-1Limestone, reaction product with bauxite and gypsumNot applicableNot applicable
91744-55-7Glycerides, lard mono-, hydrogenatedNot applicableNot applicable
93334-05-5Fatty acids, montan-wax, sodium saltsNot applicableNot applicable
93892-03-6Butanoic acid, 2-methyl-5-(1-methylethenyl)cyclohexyl ester, (1α,2β,5α)-Not applicableFragrance/ Flavourant
93892-05-8Butanoic acid, 3-methyl-, 2-methyl-5-(1-methylethenyl)cyclohexyl ester, (1α,2β,5α)-Not applicableFragrance/ Flavourant
93919-04-1Butanoic acid, 2-methyl-5-(1-methylethenyl)-2-cyclohexen-1-yl esterNot applicableFragrance/ Flavourant
93940-59-1Octanoic acid, 5-methyl-2-(1-methylethyl)cyclohexyl ester, (1α,2β,5α)-Not applicableFragrance/ Flavourant
94094-93-6Benzene, mono-C10-C13-alkyl derivs., fractionation bottoms, heavy endsNot applicableNot applicable
94248-34-7Benzoic acid, 2-[[(trimethyl-3-cyclohexen-1-yl)methylene]amino]-, methyl esterNot applicableNot applicable
94279-42-2Ferrate(4-), hexakis(cyano-C)-, oxidized N,N-dimethylbenzenamine-N-ethyl-2-methylbenzenamine-formaldehyde reaction products copper(1+) saltsNot applicableNot applicable
94386-39-7Butanoic acid, 3-methyl-, 2-methyl-5-(1-methylethenyl)-2-cyclohexen-1-yl esterNot applicableNot applicable
94386-40-0Butanoic acid, 3-methyl-, [4-(1-methylethenyl)-1-cyclohexen-1-yl]methyl esterNot applicableNot applicable
97375-25-2Platinum, carbonyl chloro 2,4,6,8-tetraethenyl-2,4,6,8-tetramethylcyclotetrasiloxane complexesNot applicableNot applicable
97862-60-7Fatty acids, C20-28, compds. with 2-(methylamino)ethanolNot applicableNot applicable
100085-57-2Oils, fish, hydrogenated, reaction products with N,N-dimethyl-1,3-propanediamine, di-Me sulfate-quaternizedNot applicableNot applicable
103443-41-0Xanthylium, 3,6-bis(diethylamino)-9-[2-(methoxycarbonyl)phenyl]-, molybdatetungstatephosphateNot applicableNot applicable
104037-85-6Benzoic acid, 2-[[3-(1,3-benzodioxol-5-yl)-2-methyl-1-propenyl]amino]-, methyl esterNot applicableFragrance/ Flavourant
106068-87-5Benzothiazolium, 5-chloro-2-[[5-[(5-chloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)ethylidene]-3-ethyl-4-oxo-2-thiazolidinylidene]methyl]-3-ethyl-, iodideYes (Ecological)Not applicable
106276-79-3Benzoic acid, 2,3,4,5-tetrachloro-6-cyano-, methyl ester, reaction products
with 2-methyl-1,3-benzenediamine and sodium methoxide
Not applicableNot applicable
106726-11-8Neodecanoic acid, neodynium(3+) saltNot applicableNot applicable
107630-41-1Nitric acid, ammonium calcium salt (11:1:5)Not applicableNot applicable
107667-02-7Phophinodithioic acid, bis(2,4,4-trimethylpentyl)-Yes (Ecological)Not applicable
109037-75-4Benzene, reaction products with chlorine and sulfur chloride (S2Cl2), hexafluoroantimonates(1-)Not applicableNot applicable
114488-10-710H-Phenothiazine, 10-[2-[(2S)-1-methyl-2-piperidinyl]ethyl]-2-(methylthio)-Not applicableNot applicable
114862-93-0Methylium, [4-(dimethylamino)phenyl]bis[4-(ethylamino)-3-methylphenyl]-, molybdatephosphateNot applicableNot applicable
114887-05-7Methylium, bis[4-(dimethylamino)phenyl][4-(ethylamino)-3-methylphenyl]-, molybdatephosphateNot applicableNot applicable
115017-00-010H-Phenothiazine-10-ethanamine, N,N-diethyl-a-methyl-, (-)-Not applicableNot applicable
117920-00-0Amines, C16-22-tert-alkyl, compds. with 2(3H)-benzothiazolethione (1:1)Not applicableNot applicable
119040-04-9Cyclohexanol, 2-methyl(trimethylbicyclo[2.2.1]hept-2-yl)-Not applicableNot applicable
119299-02-4Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, hydroxidesNot applicableNot applicable
121028-72-6Aluminum, hydroxybis(1-oxodecyl)-Not applicableNot applicable
121028-73-7Aluminum, dihydroxy(1-oxooctyl)-Not applicableNot applicable
121053-36-9Slimes and Sludges, nickel refiningNot applicableNot applicable
121053-43-8Aluminum, dihydroxy(1-oxodecyl)-Not applicableNot applicable
121754-48-1Benzenediazonium, 2-methoxy-4-(phenylamino)-, salt with 3,5-dimethylbenzenemethanesulfonic acid (1:1), reaction products with 1-(methoxymethyl)-4-(4-methylphenoxy)benzene and 1,1 '-oxybis[4-(methoxymethyl)benzene]Not applicableNot applicable
121754-49-22,4-Pentanedione, reaction products with 2-methyl-2-propanol, nonylphenol and tungsten chloride (WCl6)Not applicableNot applicable
123774-64-1Aluminum, (2-ethylhexanoato-O)dihydroxy-Not applicableNot applicable
125328-39-4Amines, N-canola-oil alkyltrimethylenedi-Not applicableNot applicable
125328-45-2Amines, hydrogenated tallow alkyl, distn., residuesNot applicableNot applicable
125328-62-3Nitriles, canola-oilNot applicableNot applicable
125328-63-4Nitriles, canola-oil, hydrogenatedNot applicableNot applicable
125328-86-12-Anthracenesulfonic acid, 1-amino-4-[[4-(1,1-dimethylethyl)phenyl]amino]-9,10-dihydro-9,10-dioxo-, monolithium saltNot applicableNot applicable
125328-87-2Benzene, 1-ethyl-2-(2-phenylethyl)-Not applicableNot applicable
125328-94-1Benzene, 1-ethyl-3-(2-phenylethyl)-Not applicableNot applicable
125494-53-3Slags, aluminum refiningNot applicableNot applicable
125494-54-4Slimes and Sludges, zinc refiningNot applicableNot applicable
126820-94-8Bicyclo[3.1.1]heptanethiol, 2,6,6-trimethyl-, gold(1+) salt, reaction products with palladium isooctyl 3-mercaptopropanoate complexes, sulfur and 2,6,6-trimethylbicyclo[3.1.1]heptanethiol silver(1+) saltNot applicableNot applicable
126820-96-0Bicyclo[3.1.1]heptanethiol, 2,6,6-trimethyl-, gold(1+) salt, reaction products with sulfur and 2,6,6-trimethylbicyclo[3.1.1]heptanethiol silver(1+) saltNot applicableNot applicable
127032-53-5Protein hydrolyzates, poultry-featherNot applicableNot applicable
129618-38-8Solutions, nickel hydrometallurgicalNot applicableNot applicable
132373-76-32-Naphthalenesulfonic acid, 1,5-bis(1-methylethyl)-, compd. with cyclohexanamine (1:1)Yes (Ecological)Not applicable
134098-61-6Benzoic acid, 4-[[[(E)-[(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]-, 1,1-dimethylethyl esterNot applicableNot applicable
143106-84-72-Butanone, 4-[[[1,2,3,4,4a,9,10,10a- octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl ]methyl](3-oxo-3-phenylpropyl)amino]-, hydrochloride, [1R-(1α,4aα)]-Yes (Ecological)Not applicable
152923-48-3Amylase, α-, Bacillus amyloliquefaciensNot applicableNot applicable

a This substance was not identified under subsection 73(1) of CEPA but was included in this assessment as it was considered as priorities based on other human health concerns.

*Additional details on use type flagged are provided in the Human Health Component.

Appendix D: Masked substances identified as not meeting the criteria under section 64 of CEPA 1999

Masked substances identified as not meeting the criteria under section 64 of CEPA 1999
CDSL numberMasked Name
10003-4Sulfurized alkyl phenols
10004-5Maleic acid reaction product with alkyl amine
10034-8Alkylsalicylic acid, zinc salt
10035-0Alkylsalicylic acid, zinc salt
10688-5Alkylsalicylic acid, sodium salt
10701-0Adipic acid, product with C16C18 alcohols and alkenylsuccinic anhydride
11005-7Dialkyl(alkyldimethylsiloxy)aluminum
11035-1DiethaNolamine salts of mono- and bis(1H,1H,2H,2H-perfluoroalkyl)phosphates
11043-0Diethylene triamine distearamide diglycidyl ether
11099-22,4-Alkyldione metal salt
11140-7Substituted phosphindithioate, zinc salt
11163-3N,N',N''-(Tris-(2-hydroxyethyl)-N-(alkyl-1,3-diaminopropane)), molybdate
11166-6Soybean oil product with sulfur and alkene and organic acid
11192-5Bisalkoxylated aluminum acetoacetic ester chelate
11193-6Fatty acids, C18-unsaturated, dimers, distillation, lights, esters with a monohydric alcohol
11194-7Bis alkoxylated aluminum acetoacetic ester chelate
11199-3Modified tri-oxyaluminum alkanoate
11204-8Ethoxylated alkyl alcohol phosphate salts of alkyl octahydrophenanthridine
11444-5Substituted aromatic diisocyanate - hydroxypropyl methacrylate resin
11500-71-Methyl, N-methoxycarbonyl, N'-[2-(perfluoroalkyl)ethoxy]carbonyl-2,4-diaminobenzene
11517-6Monodithiocarbamate of amines, N-(3-aminopropyl)-N-alkyl-, trimethylenedi-
11519-8Reaction product of dicyclopentadiene, naphtha, (petroleum), steam cracked middle aromatics, maleic anhydride and terpene
11522-2Fatty acids, reaction products with maleic anhydride and oleylamine
11523-3Fatty acids, reaction products with maleic anhydride and oleylamine, ethoxylated
11524-4Fatty acids, reaction products with maleic anhydride and triethanolamine
11525-5Fatty acids, maleated
11554-7Fatty acids, reaction products with maleic anhydride and oleylamine, ethoxylated
11560-4Diethylene glycol bis(phenyl mercury alkenyl)succinate
11561-5Diethylene glycol bis(phenyl mercury alkenyl)succinate
11562-6Diethylene glycol bis(phenyl mercury alkenyl)succinate
11013-6Polymeric monobutyltin(alkylmercaptoacetate ester), substituted
11060-82-Propanol, titanium (4+) salt, polymer with triethoxyvinylsilane;

 

Appendix E: Substances proposed not to meet Section 64 of CEPA 1999 but that were identified as having hazard classifications by other national or international agencies

Substances proposed not to meet Section 64 of CEPA 1999 but that were identified as having hazard classifications by other national or international agencies
*CAS RNaDomestic Substances List Name
51-48-9L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
101-65-5Carbamic acid, (methylenedi-4,1-phenylene)bis-, diphenyl ester
123-69-3Oxacycloheptadec-8-en-2-one, (Z)-
302-79-4Retinoic acid
751-94-029-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, monosodium salt, (3α,4α,8α,9β,11α,13α, 14β,16β,17Z)-
1796-92-5Benzoic acid, 5-[(3-carboxy-5-methyl-4-oxo-2,5-cyclohexadien-1-ylidene)(2,6-dichlorophenyl)methyl]-2-hydroxy-3-methyl-, disodium salt
2944-30-19,10-Anthracenedione, 1,4-bis[(4-methoxyphenyl)amino]-
3910-35-81H-Indene, 2,3-dihydro-1,1,3-trimethyl-3-phenyl-
4091-99-0Benzoic acid, 2-[3,6-bis(acetyloxy)-2,7-dichloro-9H-xanthen-9-yl]-
5284-79-7Cyclohexanone, 2,6-bis[(4-azidophenyl)methylene]-4-methyl-
7717-62-6Benzeneacetic acid, 1-phenyl-1,2-ethanediyl ester
7774-29-0Mercury iodide (HgI2)
19014-53-09,10-Anthracenedione, 1-amino-2-[4-[(hexahydro-2-oxo-1H-azepin-1-yl)methyl]phenoxy]-4-hydroxy-
41284-31-51,4-Benzenedicarboxylic acid, 2-[[4-(2,2-dicyanoethenyl)-3-methylphenyl]ethylamino]ethyl methyl ester
47742-71-2Xanthylium, 3,6-bis(diethylamino)-9-[2-(methoxycarbonyl)phenyl]-
52236-80-3Acetic acid, [4-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthracenyl)oxy]phenoxy]-, ethyl ester
61790-11-2Fatty acids, tall-oil, zinc salts
61790-54-3Naphthenic acids, compds. with N-tallow alkyltrimethylenediamines
63148-76-5Benzoxazolium, 3-ethyl-5-phenyl-2-[2-[[3-(3-sulfopropyl)-2(3H)-benzoxazolylidene]methyl]-1-butenyl]-, hydroxide, inner salt
63568-35-4Naphthalenedisulfonic acid, diisononyl-, compd. with 1,1’-iminobis[2-propanol] (1:2)
68083-40-9Methanone, [2-hydroxy-4-[2-hydroxy-3-(octyloxy)propoxy]phenyl]phenyl-
68201-19-4Barium, acetate tallow fatty acids complexes
68228-09-1Benzoic acid, 2-[[[2,4(or 3,5)-dimethyl-3-cyclohexen-1-yl]methyl]amino]-, ethyl ester
68334-11-2Fatty acids, tall oil, compds. with 2-[(2-hydroxyphenyl)methylene]hydrazinecarboximidamide
68603-64-5Amines, N-(hydrogenated tallow alkyl)trimethylenedi-
68648-44-2Pyrethrins and Pyrethroids, manufg.-residues
71487-01-9Quaternary ammonium compounds, dicoco alkyldimethyl, nitrites
106068-87-5Benzothiazolium, 5-chloro-2-[[5-[(5-chloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)ethylidene]-3-ethyl-4-oxo-2-thiazolidinylidene]methyl]-3-ethyl-, iodide
107667-02-7Phophinodithioic acid, bis(2,4,4-trimethylpentyl)-
132373-76-32-Naphthalenesulfonic acid, 1,5-bis(1-methylethyl)-, compd. with cyclohexanamine (1:1)
143106-84-72-Butanone, 4-[[[1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl]methyl](3-oxo-3-phenylpropyl)amino]-, hydrochloride, [1R-(1α,4aα)]-

a Chemical Abstracts Service Registry Number.

* Substances with iT values from Categorization below 0.0061 mg/L.

Appendix F: Substances identified as not meeting the criteria under Section 64 of CEPA 1999 but that were identified as having classifications for health effects of concern by other national or international agencies

Substances identified as not meeting the criteria under Section 64 of CEPA 1999 but that were identified as having classifications for health effects of concern by other national or international agencies
CAS RNaDomestic Substances List NameClassification for human healthReference for classification
98-95-3Benzene, nitro-Possibly carcinogenic to humans; Reasonably Anticipated To Be Human Carcinogen; Likely to be carcinogenic to human; Causes concern for humans owing to possible carcinogenic effects; Causes concern for human fertilityIARC 1996, NTP 2014; U.S. EPA 2005; ESIS 1995-2010; ESIS 1995-2010
135-88-62-Naphthalenamine, N-phenyl-Causes concern for humans owing to possible carcinogenic effectsESIS 1995-2010
140-41-0Acetic acid, trichloro-, compd. with N '-(4-chlorophenyl)-N,N-dimethylurea (1:1)Causes concern for humans owing to possible carcinogenic effectsESIS 1995-2010
1314-20-1Thorium oxideKnown To Be Human CarcinogenNTP 2014
6804-07-5Hydrazinecarboxylic acid, [(1,4-dioxido-2-quinoxalinyl)methylene]-, methyl esterRegarded as if carcinogenic to humansESIS 1995-2010
14816-18-33,5-Dioxa-6-aza-4-phosphaoct-6-ene-8-nitrile, 4-ethoxy-7-phenyl-, 4-sulfideCauses concern for human fertilityESIS 1995-2010
50471-44-82,4-Oxazolidinedione, 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-Causes concern for humans owing to possible carcinogenic effects; Regarded as if they cause developmental toxicity in humans; Regarded as if they impair fertility in humansESIS 1995-2010
68610-24-2C.I. Pigment Yellow 157Known to be carcinogenic to humansESIS 1995-2010

a Chemical Abstracts Service Registry Number

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