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ARCHIVED - PSL Assessment Report for Aluminum Salts
- List of Figures
- List of Tables
- List of Acronyms and Abbreviations
- Synopsis
- 1. Introduction
- 2. Summary of Information Critical to Assessment of "Toxic" Under CEPA 1999
- 2.1 Identity and physical/chemical properties
- 2.2 Entry characterization
- 2.3 Exposure Characterization
- 2.4 Effects characterization
- 3. Assessment of "Toxic" Under CEPA 1999
- 3.1 CEPA 1999 64(a) and 64(b) Environment
- 3.2 CEPA 1999 64(c): Human health
- 3.3 Conclusion
- References
- Appendix A
- Appendix B
- Appendix C
List of Acronyms and Abbreviations
- Aβ
- amyloid beta
- ACH
- aluminum chlorohydrate
- AD
- Alzheimer's disease
- ADAF
- chemical-specific animal to human toxicodynamic adjustment factor
- ADP
- adenosine diphosphate
- ADRDA
- Alzheimer's Disease and Related Disorders Association
- AKAF
- chemical-specific animal to human toxicokinetic adjustment factor
- AMS
- accelerator mass spectrometry
- ApoE
- apolipoprotein E
- ASFA
- Aquatic Sciences and Fisheries Abstracts (World Health Organization Food and Agricultural Organization)
- ATP
- adenosine triphosphate
- ATPase
- class of enzymes that catalyze the decomposition of ATP into ADP
- ATSDR
- Agency for Toxic Substances and Disease Registry (U.S. Department of Health and Human Services)
- BAF
- bioaccumulation factor
- BCF
- bioconcentration factor
- BIOSIS
- Biosciences Information Services
- CAplus
- Chemical Abstracts Plus
- CAB
- Commonwealth Agricultural Bureaux
- cAMP
- cyclic adenosine monophosphate
- CAS
- Chemical Abstracts Service
- CASReact
- CAS Reaction
- CBTB
- Canadian Brain Tissue Bank
- CEPA
- Canadian Environmental Protection Act
- CEPA 1999
- Canadian Environmental Protection Act, 1999
- CESARS
- Chemical Evaluation Search and Retrieval System (Ontario Ministry of the Environment and Michigan Department of Natural Resources)
- cGMP
- cyclic guanosine monophosphate
- ChemCats
- Chemical Catalogs online
- Chemlist
- regulated Chemicals Listing
- CHRIS
- Chemical Hazard Release Information System
- CI
- confidence interval
- CSHA
- Canadian Study of Health and Aging
- CT
- computer tomography
- CTV
- Critical Toxicity Value
- Da
- administered dose
- Db
- base diet dose
- Dc
- cumulative dose
- DIN
- Drug Identification Number
- DNA
- deoxyribonucleic acid
- DOC
- dissolved organic carbon
- DOM
- dissolved organic material
- DSM
- Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association)
- dw
- dry weight
- DWTP
- drinking water treatment plant
- EC50
- median effective concentration
- ECETOC
- European Centre for Ecotoxicology and Toxicology of Chemicals
- EDI
- estimated daily intake
- EEM
- Environmental Effects Monitoring
- ELIAS
- Environmental Library Integrated Automated System (Environment Canada library)
- EPA
- Environmental Protection Agency (U.S.)
- ETAAS
- electrothermal atomic absorption spectroscopy
- FAO
- Food and Agricultural Organization (United Nations)
- GD
- gestational day
- GEOREF
- Geo Reference Information System (American Geological Institute)
- GLP
- good laboratory practice
- GVRD
- Greater Vancouver Regional District
- GVS&DD
- Greater Vancouver Sewerage & Drainage District
- HDAF
- chemical-specific human variability toxicodynamic adjustment factor
- HKAF
- chemical-specific human variability toxicokinetic adjustment factor
- HSDB
- Hazardous Substances Data Bank (U.S. National Library of Medicine)
- ICD
- International Classification of Diseases (World Health Organization)
- IM
- intramuscular
- IPCS
- International Programme on Chemical Safety (World Health Organization)
- IV
- intravenous
- JECFA
- Joint FAO/WHO Expert Committee on Food Additives
- KASAL
- alkaline aluminum phosphate and dibasic sodium phosphate
- LC50
- median lethal concentration
- LD50
- median lethal dose
- LOAEC
- lowest observed adverse effect concentration
- LOEC
- lowest observed effect concentration
- LOEL
- lowest observed effect level
- LSA
- Ontario Longitudinal study of Aging
- MEDLINE
- Medical Literature Analysis and Retrieval System Online (U.S. National Library of Medicine)
- MINEQL+
- chemical equilibrium modeling software
- MMAD
- mass median aerodynamic diameter
- MMSE
- Mini-Mental State Examination
- MOE
- margin of exposure
- mRNA
- messenger ribonucleic acid
- MS
- multiple sclerosis
- MWWTP
- municipal wastewater treatment plant
- NADPH
- nicotinamide adenine dinucleotide phosphate
- NATES
- National Analysis of Trends in Emergencies System
- NEMISIS
- National Enforcement Management Information System and Intelligence System
- NFT
- neurofibrillary tangles
- NICNAS
- National Industrial Chemicals Notification and Assessment Scheme (Australian Government Department of Health and Aging)
- NIH
- National Institutes of Health (U.S. Department of Health and Human Services)
- NINCDS
- National Institute of Neurological and Communicative Disorders and Stroke
- NOEC
- no observed effect concentration
- NOEL
- no observed effect level
- NTIS
- National Technical Information Service (U.S. Department of Commerce)
- OECD
- Organisation for Economic Co-Operation and Development
- OR
- odds ratio
- p value
- the probability of obtaining a value of the test statistic at least as extreme as the one that was actually observed, given that the null hypothesis is true
- PAC
- polyaluminum chloride
- PAQUID
- Principle lifetime occupation and cognitive impairment in a French elderly
- PAS
- polyaluminum sulphate
- PASS
- polyaluminum silicate sulphate
- PEC
- Predicted Environmental Concentration
- PM
- particulate matter
- PM2.5
- particulate matter less than 2.5 micrometers in aerodynamic diameter
- PM10
- particulate matter less than 10 micrometers in aerodynamic diameter
- PND
- postnatal day
- PNEC
- Predicted No-Effect Concentration
- POLTOX
- Cambridge Scientific Abstracts (U.S. National Library of Medicine)
- PPP2
- Protein Phosphatase 2
- PSL
- Priority Substances List
- PSL2
- Second Priority Substances List
- PTEAM
- Particle Total Exposure Assessment Methodology
- PubMed
- free Internet access to MEDLINE
- RMOC
- Regional Municipality of Ottawa-Carleton
- RR
- relative risk
- RTECS
- Registry of Toxic Effects of Chemical Substances (U.S. National Institute for Occupational Safety and Health)
- SALP
- sodium aluminum phosphate
- SOS
- State of the Science
- t½
- half-life
- TDI
- total dietary intake
- Tf
- transferrin
- TNF-α
- alpha tumour necrosis factor
- TOXLINE
- toxicology database (U.S. National Library of Medicine)
- TRI93
- Toxic Chemical Release Inventory (U.S. Environmental Protection Agency, Office of Toxic Substances)
- TSS
- total suspended solids
- USEPA-ASTER
- Assessment Tools for the Evaluation of Risk (U.S. Environmental Protection Agency)
- Vd
- volumes of distribution
- WASTEINFO
- Waste Management Information (Bureau of the American Energy Agency)
- WHAM
- Windermere Humic-Aqueous Model software designed to calculate equilibrium chemical speciation in surface and ground waters, sediments and soils
- WHO
- World Health Organization
- Date modified: